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Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling.
Felcht M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, Bartol A, Kienast Y, Vettel C, Loos EK, Kutschera S, Bartels S, Appak S, Besemfelder E, Terhardt D, Chavakis E, Wieland T, Klein C, Thomas M, Uemura A, Goerdt S, Augustin HG. Felcht M, et al. Among authors: augustin hg. J Clin Invest. 2012 Jun;122(6):1991-2005. doi: 10.1172/JCI58832. Epub 2012 May 15. J Clin Invest. 2012. PMID: 22585576 Free PMC article.
Angiopoietin-2 is critical for cytokine-induced vascular leakage.
Benest AV, Kruse K, Savant S, Thomas M, Laib AM, Loos EK, Fiedler U, Augustin HG. Benest AV, et al. Among authors: augustin hg. PLoS One. 2013 Aug 5;8(8):e70459. doi: 10.1371/journal.pone.0070459. Print 2013. PLoS One. 2013. PMID: 23940579 Free PMC article.
Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy.
Kienast Y, Klein C, Scheuer W, Raemsch R, Lorenzon E, Bernicke D, Herting F, Yu S, The HH, Martarello L, Gassner C, Stubenrauch KG, Munro K, Augustin HG, Thomas M. Kienast Y, et al. Among authors: augustin hg. Clin Cancer Res. 2013 Dec 15;19(24):6730-40. doi: 10.1158/1078-0432.CCR-13-0081. Epub 2013 Oct 4. Clin Cancer Res. 2013. PMID: 24097868
212 results