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Chromosome 8 gain is associated with high-grade transformation in MPNST.
Dehner C, Moon CI, Zhang X, Zhou Z, Miller C, Xu H, Wan X, Yang K, Mashl J, Gosline SJ, Wang Y, Zhang X, Godec A, Jones PA, Dahiya S, Bhatia H, Primeau T, Li S, Pollard K, Rodriguez FJ, Ding L, Pratilas CA, Shern JF, Hirbe AC. Dehner C, et al. Among authors: zhang x. JCI Insight. 2021 Mar 22;6(6):e146351. doi: 10.1172/jci.insight.146351. JCI Insight. 2021. PMID: 33591953 Free PMC article.
Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, Gutmann DH. Hirbe AC, et al. Among authors: zhang x. Clin Cancer Res. 2015 Sep 15;21(18):4201-11. doi: 10.1158/1078-0432.CCR-14-3049. Epub 2015 Apr 29. Clin Cancer Res. 2015. PMID: 25925892 Free PMC article.
Unmasking Intra-tumoral Heterogeneity and Clonal Evolution in NF1-MPNST.
Moon CI, Tompkins W, Wang Y, Godec A, Zhang X, Pipkorn P, Miller CA, Dehner C, Dahiya S, Hirbe AC. Moon CI, et al. Among authors: zhang x. Genes (Basel). 2020 May 1;11(5):499. doi: 10.3390/genes11050499. Genes (Basel). 2020. PMID: 32369930 Free PMC article.
Whole exome sequencing reveals the maintained polyclonal nature from primary to metastatic malignant peripheral nerve sheath tumor in two patients with NF1.
Godec A, Jayasinghe R, Chrisinger JSA, Prudner B, Ball T, Wang Y, Srihari D, Kaushal M, Dietz H, Zhang X, Pekmezci M, Dahiya S, Tao Y, Luo J, Van Tine BA, Ding L, Gutmann DH, Hirbe AC. Godec A, et al. Among authors: zhang x. Neurooncol Adv. 2019 Sep 10;2(Suppl 1):i75-i84. doi: 10.1093/noajnl/vdz026. eCollection 2020 Jul. Neurooncol Adv. 2019. PMID: 32642734 Free PMC article.
CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon restoration of RB function in malignant peripheral nerve sheath tumors.
Wang J, Calizo A, Zhang L, Pino JC, Lyu Y, Pollard K, Zhang X, Larsson AT, Conniff E, Llosa N, Wood DK, Largaespada DA, Moody SE, Gosline SJ, Hirbe AC, Pratilas CA. Wang J, et al. Among authors: zhang l, zhang x. bioRxiv [Preprint]. 2023 Feb 3:2023.02.02.526674. doi: 10.1101/2023.02.02.526674. bioRxiv. 2023. Update in: Sci Adv. 2023 Nov 24;9(47):eadg8876. doi: 10.1126/sciadv.adg8876 PMID: 36778419 Free PMC article. Updated. Preprint.
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