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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types.
Finucane HK, Reshef YA, Anttila V, Slowikowski K, Gusev A, Byrnes A, Gazal S, Loh PR, Lareau C, Shoresh N, Genovese G, Saunders A, Macosko E, Pollack S; Brainstorm Consortium; Perry JRB, Buenrostro JD, Bernstein BE, Raychaudhuri S, McCarroll S, Neale BM, Price AL. Finucane HK, et al. Among authors: gazal s. Nat Genet. 2018 Apr;50(4):621-629. doi: 10.1038/s41588-018-0081-4. Epub 2018 Apr 9. Nat Genet. 2018. PMID: 29632380 Free PMC article.
Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits.
Evans LM, Tahmasbi R, Vrieze SI, Abecasis GR, Das S, Gazal S, Bjelland DW, de Candia TR; Haplotype Reference Consortium; Goddard ME, Neale BM, Yang J, Visscher PM, Keller MC. Evans LM, et al. Among authors: gazal s. Nat Genet. 2018 May;50(5):737-745. doi: 10.1038/s41588-018-0108-x. Epub 2018 Apr 26. Nat Genet. 2018. PMID: 29700474 Free PMC article.
Mixed-model association for biobank-scale datasets.
Loh PR, Kichaev G, Gazal S, Schoech AP, Price AL. Loh PR, et al. Among authors: gazal s. Nat Genet. 2018 Jul;50(7):906-908. doi: 10.1038/s41588-018-0144-6. Nat Genet. 2018. PMID: 29892013 Free PMC article.
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk.
Reshef YA, Finucane HK, Kelley DR, Gusev A, Kotliar D, Ulirsch JC, Hormozdiari F, Nasser J, O'Connor L, van de Geijn B, Loh PR, Grossman SR, Bhatia G, Gazal S, Palamara PF, Pinello L, Patterson N, Adams RP, Price AL. Reshef YA, et al. Among authors: gazal s. Nat Genet. 2018 Oct;50(10):1483-1493. doi: 10.1038/s41588-018-0196-7. Epub 2018 Sep 3. Nat Genet. 2018. PMID: 30177862 Free PMC article.
116 results