Schoech AP - Search Results

1

Population-specific causal disease effect sizes in functionally important regions impacted by selection.

Shi H, Gazal S, Kanai M, Koch EM, Schoech AP, Siewert KM, Kim SS, Luo Y, Amariuta T, Huang H, Okada Y, Raychaudhuri S, Sunyaev SR, Price AL. Shi H, et al. Among authors: schoech ap. Nat Commun. 2021 Feb 17;12(1):1098. doi: 10.1038/s41467-021-21286-1. Nat Commun. 2021. PMID: 33597505 Free PMC article.

2

Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection.

Gazal S, Finucane HK, Furlotte NA, Loh PR, Palamara PF, Liu X, Schoech A, Bulik-Sullivan B, Neale BM, Gusev A, Price AL. Gazal S, et al. Nat Genet. 2017 Oct;49(10):1421-1427. doi: 10.1038/ng.3954. Epub 2017 Sep 11. Nat Genet. 2017. PMID: 28892061 Free PMC article.

3

Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits.

Hormozdiari F, Gazal S, van de Geijn B, Finucane HK, Ju CJ, Loh PR, Schoech A, Reshef Y, Liu X, O'Connor L, Gusev A, Eskin E, Price AL. Hormozdiari F, et al. Nat Genet. 2018 Jul;50(7):1041-1047. doi: 10.1038/s41588-018-0148-2. Epub 2018 Jun 25. Nat Genet. 2018. PMID: 29942083 Free PMC article.

4

Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations.

Gazal S, Loh PR, Finucane HK, Ganna A, Schoech A, Sunyaev S, Price AL. Gazal S, et al. Nat Genet. 2018 Nov;50(11):1600-1607. doi: 10.1038/s41588-018-0231-8. Epub 2018 Oct 8. Nat Genet. 2018. PMID: 30297966 Free PMC article.

5

Mixed-model association for biobank-scale datasets.

Loh PR, Kichaev G, Gazal S, Schoech AP, Price AL. Loh PR, et al. Among authors: schoech ap. Nat Genet. 2018 Jul;50(7):906-908. doi: 10.1038/s41588-018-0144-6. Nat Genet. 2018. PMID: 29892013 Free PMC article.

6

Quantification of frequency-dependent genetic architectures in 25 UK Biobank traits reveals action of negative selection.

Schoech AP, Jordan DM, Loh PR, Gazal S, O'Connor LJ, Balick DJ, Palamara PF, Finucane HK, Sunyaev SR, Price AL. Schoech AP, et al. Nat Commun. 2019 Feb 15;10(1):790. doi: 10.1038/s41467-019-08424-6. Nat Commun. 2019. PMID: 30770844 Free PMC article.

7

Extreme Polygenicity of Complex Traits Is Explained by Negative Selection.

O'Connor LJ, Schoech AP, Hormozdiari F, Gazal S, Patterson N, Price AL. O'Connor LJ, et al. Among authors: schoech ap. Am J Hum Genet. 2019 Sep 5;105(3):456-476. doi: 10.1016/j.ajhg.2019.07.003. Epub 2019 Aug 8. Am J Hum Genet. 2019. PMID: 31402091 Free PMC article.

8

Functionally informed fine-mapping and polygenic localization of complex trait heritability.

Weissbrod O, Hormozdiari F, Benner C, Cui R, Ulirsch J, Gazal S, Schoech AP, van de Geijn B, Reshef Y, Márquez-Luna C, O'Connor L, Pirinen M, Finucane HK, Price AL. Weissbrod O, et al. Among authors: schoech ap. Nat Genet. 2020 Dec;52(12):1355-1363. doi: 10.1038/s41588-020-00735-5. Epub 2020 Nov 16. Nat Genet. 2020. PMID: 33199916 Free PMC article.

9

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

Kichaev G, Bhatia G, Loh PR, Gazal S, Burch K, Freund MK, Schoech A, Pasaniuc B, Price AL. Kichaev G, et al. Am J Hum Genet. 2019 Jan 3;104(1):65-75. doi: 10.1016/j.ajhg.2018.11.008. Epub 2018 Dec 27. Am J Hum Genet. 2019. PMID: 30595370 Free PMC article.

10

Author Correction: Linkage disequilibrium-dependent architecture of human complex traits shows action of negative selection.

Gazal S, Finucane HK, Furlotte NA, Loh PR, Palamara PF, Liu X, Schoech A, Bulik-Sullivan B, Neale BM, Gusev A, Price AL. Gazal S, et al. Nat Genet. 2019 Aug;51(8):1295. doi: 10.1038/s41588-019-0468-x. Nat Genet. 2019. PMID: 31273336

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