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Tuberculosis drug discovery and emerging targets.
Mdluli K, Kaneko T, Upton A. Mdluli K, et al. Ann N Y Acad Sci. 2014 Sep;1323:56-75. doi: 10.1111/nyas.12459. Epub 2014 Jun 11. Ann N Y Acad Sci. 2014. PMID: 24920100 Review.
Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units.
Choi PJ, Sutherland HS, Tong AST, Blaser A, Franzblau SG, Cooper CB, Lotlikar MU, Upton AM, Guillemont J, Motte M, Queguiner L, Andries K, Van den Broeck W, Denny WA, Palmer BD. Choi PJ, et al. Among authors: upton am. Bioorg Med Chem Lett. 2017 Dec 1;27(23):5190-5196. doi: 10.1016/j.bmcl.2017.10.042. Epub 2017 Oct 20. Bioorg Med Chem Lett. 2017. PMID: 29107541 Free PMC article.
Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles.
Sutherland HS, Tong AST, Choi PJ, Conole D, Blaser A, Franzblau SG, Cooper CB, Upton AM, Lotlikar MU, Denny WA, Palmer BD. Sutherland HS, et al. Among authors: upton am. Bioorg Med Chem. 2018 May 1;26(8):1797-1809. doi: 10.1016/j.bmc.2018.02.026. Epub 2018 Feb 20. Bioorg Med Chem. 2018. PMID: 29482950 Free PMC article.
Contribution of Pretomanid to Novel Regimens Containing Bedaquiline with either Linezolid or Moxifloxacin and Pyrazinamide in Murine Models of Tuberculosis.
Xu J, Li SY, Almeida DV, Tasneen R, Barnes-Boyle K, Converse PJ, Upton AM, Mdluli K, Fotouhi N, Nuermberger EL. Xu J, et al. Among authors: upton am. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e00021-19. doi: 10.1128/AAC.00021-19. Print 2019 May. Antimicrob Agents Chemother. 2019. PMID: 30833432 Free PMC article.
49 results