Hadden MK - Search Results

1

Structure-based virtual screening identifies an 8-hydroxyquinoline as a small molecule GLI1 inhibitor.

Dash RC, Wen J, Zaino AM, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. Dash RC, et al. Among authors: hadden mk. Mol Ther Oncolytics. 2021 Jan 16;20:265-276. doi: 10.1016/j.omto.2021.01.004. eCollection 2021 Mar 26. Mol Ther Oncolytics. 2021. PMID: 33614910 Free PMC article.

2

Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic.

Pace JR, DeBerardinis AM, Sail V, Tacheva-Grigorova SK, Chan KA, Tran R, Raccuia DS, Wechsler-Reya RJ, Hadden MK. Pace JR, et al. Among authors: hadden mk. J Med Chem. 2016 Apr 28;59(8):3635-49. doi: 10.1021/acs.jmedchem.5b01718. Epub 2016 Apr 6. J Med Chem. 2016. PMID: 27014922 Free PMC article.

3

A molecular dynamics approach to identify an oxysterol-based hedgehog pathway inhibitor.

Dash RC, Maschinot CR, Hadden MK. Dash RC, et al. Among authors: hadden mk. Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):168-177. doi: 10.1016/j.bbagen.2016.11.003. Epub 2016 Nov 5. Biochim Biophys Acta Gen Subj. 2017. PMID: 27825830

4

Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein-Protein Interaction.

Sail V, Rizzo AA, Chatterjee N, Dash RC, Ozen Z, Walker GC, Korzhnev DM, Hadden MK. Sail V, et al. Among authors: hadden mk. ACS Chem Biol. 2017 Jul 21;12(7):1903-1912. doi: 10.1021/acschembio.6b01144. Epub 2017 Jun 9. ACS Chem Biol. 2017. PMID: 28541665 Free PMC article.

5

Structure-Activity Relationship Studies of Vitamin D3 Analogues Containing an Ether or Thioether Linker as Hedgehog Pathway Inhibitors.

Wen J, Hadden MK. Wen J, et al. Among authors: hadden mk. ChemMedChem. 2018 Apr 6;13(7):748-753. doi: 10.1002/cmdc.201700792. Epub 2018 Feb 27. ChemMedChem. 2018. PMID: 29409113

6

A metadynamic approach to understand the recognition mechanism of the histone H3 tail with the ATRX_ADD domain.

Dash RC, Zaino AM, Hadden MK. Dash RC, et al. Among authors: hadden mk. Biochim Biophys Acta Gene Regul Mech. 2018 Jun;1861(6):594-602. doi: 10.1016/j.bbagrm.2018.05.001. Epub 2018 May 3. Biochim Biophys Acta Gene Regul Mech. 2018. PMID: 29730439

7

Small molecule scaffolds that disrupt the Rev1-CT/RIR protein-protein interaction.

Ozen Z, Dash RC, McCarthy KR, Chow SA, Rizzo AA, Korzhnev DM, Hadden MK. Ozen Z, et al. Among authors: hadden mk. Bioorg Med Chem. 2018 Aug 7;26(14):4301-4309. doi: 10.1016/j.bmc.2018.07.029. Epub 2018 Jul 19. Bioorg Med Chem. 2018. PMID: 30037752

8

Structural Approach To Identify a Lead Scaffold That Targets the Translesion Synthesis Polymerase Rev1.

Dash RC, Ozen Z, Rizzo AA, Lim S, Korzhnev DM, Hadden MK. Dash RC, et al. Among authors: hadden mk. J Chem Inf Model. 2018 Nov 26;58(11):2266-2277. doi: 10.1021/acs.jcim.8b00535. Epub 2018 Oct 19. J Chem Inf Model. 2018. PMID: 30289707

9

Synthesis and evaluation of third generation vitamin D3 analogues as inhibitors of Hedgehog signaling.

Maschinot CA, Chau LQ, Wechsler-Reya RJ, Hadden MK. Maschinot CA, et al. Among authors: hadden mk. Eur J Med Chem. 2019 Jan 15;162:495-506. doi: 10.1016/j.ejmech.2018.11.028. Epub 2018 Nov 10. Eur J Med Chem. 2019. PMID: 30471551

10

Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors.

Teske KA, Dash RC, Morel SR, Chau LQ, Wechsler-Reya RJ, Hadden MK. Teske KA, et al. Among authors: hadden mk. Eur J Med Chem. 2019 Feb 1;163:320-332. doi: 10.1016/j.ejmech.2018.11.056. Epub 2018 Nov 23. Eur J Med Chem. 2019. PMID: 30529635 Free PMC article.

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