Wu H - Search Results

1

Resistance to Pyrrolobenzodiazepine Dimers Is Associated with SLFN11 Downregulation and Can Be Reversed through Inhibition of ATR.

Mao S, Chaerkady R, Yu W, D'Angelo G, Garcia A, Chen H, Barrett AM, Phipps S, Fleming R, Hess S, Koopmann JO, Dimasi N, Wilson S, Pugh K, Cook K, Masterson LA, Gao C, Wu H, Herbst R, Howard PW, Tice DA, Cobbold M, Harper J. Mao S, et al. Among authors: wu h. Mol Cancer Ther. 2021 Mar;20(3):541-552. doi: 10.1158/1535-7163.MCT-20-0351. Mol Cancer Ther. 2021. PMID: 33653945

2

Development of a Trispecific Antibody Designed to Simultaneously and Efficiently Target Three Different Antigens on Tumor Cells.

Dimasi N, Fleming R, Hay C, Woods R, Xu L, Wu H, Gao C. Dimasi N, et al. Among authors: wu h. Mol Pharm. 2015 Sep 8;12(9):3490-501. doi: 10.1021/acs.molpharmaceut.5b00268. Epub 2015 Aug 4. Mol Pharm. 2015. PMID: 26176328

3

Straightforward Glycoengineering Approach to Site-Specific Antibody-Pyrrolobenzodiazepine Conjugates.

Thompson P, Ezeadi E, Hutchinson I, Fleming R, Bezabeh B, Lin J, Mao S, Chen C, Masterson L, Zhong H, Toader D, Howard P, Wu H, Gao C, Dimasi N. Thompson P, et al. Among authors: wu h. ACS Med Chem Lett. 2016 Sep 20;7(11):1005-1008. doi: 10.1021/acsmedchemlett.6b00278. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882199 Free PMC article.

4

Efficient Preparation of Site-Specific Antibody-Drug Conjugates Using Cysteine Insertion.

Dimasi N, Fleming R, Zhong H, Bezabeh B, Kinneer K, Christie RJ, Fazenbaker C, Wu H, Gao C. Dimasi N, et al. Among authors: wu h. Mol Pharm. 2017 May 1;14(5):1501-1516. doi: 10.1021/acs.molpharmaceut.6b00995. Epub 2017 Mar 16. Mol Pharm. 2017. PMID: 28245132

5

Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads.

Kumar A, Kinneer K, Masterson L, Ezeadi E, Howard P, Wu H, Gao C, Dimasi N. Kumar A, et al. Among authors: wu h. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3617-3621. doi: 10.1016/j.bmcl.2018.10.043. Epub 2018 Oct 26. Bioorg Med Chem Lett. 2018. PMID: 30389292

6

Characterization and in vitro data of antibody drug conjugates (ADCs) derived from heterotrifunctional linker designed for the site-specific preparation of dual ADCs.

Kumar A, Kinneer K, Masterson L, Ezeadi E, Howard P, Wu H, Gao C, Dimasi N. Kumar A, et al. Among authors: wu h. Data Brief. 2018 Nov 6;21:2208-2220. doi: 10.1016/j.dib.2018.11.005. eCollection 2018 Dec. Data Brief. 2018. PMID: 30533469 Free PMC article.

7

Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.

White JB, Fleming R, Masterson L, Ruddle BT, Zhong H, Fazenbaker C, Strout P, Rosenthal K, Reed M, Muniz-Medina V, Howard P, Dixit R, Wu H, Hinrichs MJ, Gao C, Dimasi N. White JB, et al. Among authors: wu h. MAbs. 2019 Apr;11(3):500-515. doi: 10.1080/19420862.2019.1578611. Epub 2019 Mar 5. MAbs. 2019. PMID: 30835621 Free PMC article.

8

Characterization of Disulfide Bond Rebridged Fab-Drug Conjugates Prepared Using a Dual Maleimide Pyrrolobenzodiazepine Cytotoxic Payload.

Ruddle BT, Fleming R, Wu H, Gao C, Dimasi N. Ruddle BT, et al. Among authors: wu h. ChemMedChem. 2019 Jun 18;14(12):1185-1195. doi: 10.1002/cmdc.201900077. Epub 2019 May 3. ChemMedChem. 2019. PMID: 30980702

9

Pyrrolobenzodiazepine Antibody-Drug Conjugates Designed for Stable Thiol Conjugation.

Christie RJ, Tiberghien AC, Du Q, Bezabeh B, Fleming R, Shannon A, Mao S, Breen S, Zhang J, Zhong H, Harper J, Wu H, Howard PW, Gao C. Christie RJ, et al. Among authors: wu h. Antibodies (Basel). 2017 Nov 28;6(4):20. doi: 10.3390/antib6040020. Antibodies (Basel). 2017. PMID: 31548535 Free PMC article.

10

A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo.

Jackson D, Gooya J, Mao S, Kinneer K, Xu L, Camara M, Fazenbaker C, Fleming R, Swamynathan S, Meyer D, Senter PD, Gao C, Wu H, Kinch M, Coats S, Kiener PA, Tice DA. Jackson D, et al. Among authors: wu h. Cancer Res. 2008 Nov 15;68(22):9367-74. doi: 10.1158/0008-5472.CAN-08-1933. Cancer Res. 2008. PMID: 19010911

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