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A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Scott DE, Francis-Newton NJ, Marsh ME, Coyne AG, Fischer G, Moschetti T, Bayly AR, Sharpe TD, Haas KT, Barber L, Valenzano CR, Srinivasan R, Huggins DJ, Lee M, Emery A, Hardwick B, Ehebauer M, Dagostin C, Esposito A, Pellegrini L, Perrior T, McKenzie G, Blundell TL, Hyvönen M, Skidmore J, Venkitaraman AR, Abell C. Scott DE, et al. Among authors: pellegrini l. Cell Chem Biol. 2021 Jun 17;28(6):835-847.e5. doi: 10.1016/j.chembiol.2021.02.006. Epub 2021 Mar 3. Cell Chem Biol. 2021. PMID: 33662256 Free PMC article.
Sequence analyses and comparative modeling of fly and worm fibroblast growth factor receptors indicate that the determinants for FGF and heparin binding are retained in evolution.
Nagendra HG, Harrington AE, Harmer NJ, Pellegrini L, Blundell TL, Burke DF. Nagendra HG, et al. Among authors: pellegrini l. FEBS Lett. 2001 Jul 13;501(1):51-8. doi: 10.1016/s0014-5793(01)02603-5. FEBS Lett. 2001. PMID: 11457455 Free article.
We have analysed the sequences of worm and fly FGFs and FGFRs and used the recently determined crystal structure of the human FGF1-FGFR2-heparin ternary complex [Pellegrini, L., Burke, D.F., von Delft, F., Mulloy, B. and Blundell, T.L. (2000) Nature 407, 1029 …
We have analysed the sequences of worm and fly FGFs and FGFRs and used the recently determined crystal structure of the human FGF1-FGFR2-hep …
Crystal structure of an Xrcc4-DNA ligase IV complex.
Sibanda BL, Critchlow SE, Begun J, Pei XY, Jackson SP, Blundell TL, Pellegrini L. Sibanda BL, et al. Among authors: pellegrini l. Nat Struct Biol. 2001 Dec;8(12):1015-9. doi: 10.1038/nsb725. Nat Struct Biol. 2001. PMID: 11702069
The structural biology of growth factor receptor activation.
Harmer NJ, Chirgadze D, Hyun Kim K, Pellegrini L, Blundell TL. Harmer NJ, et al. Among authors: pellegrini l. Biophys Chem. 2003;100(1-3):545-53. doi: 10.1016/s0301-4622(02)00305-8. Biophys Chem. 2003. PMID: 12646390
448 results