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Utilizing Computational Machine Learning Tools to Understand Immunogenic Breadth in the Context of a CD8 T-Cell Mediated HIV Response.
McGowan E, Rosenthal R, Fiore-Gartland A, Macharia G, Balinda S, Kapaata A, Umviligihozo G, Muok E, Dalel J, Streatfield CL, Coutinho H, Dilernia D, Monaco DC, Morrison D, Yue L, Hunter E, Nielsen M, Gilmour J, Hare J. McGowan E, et al. Among authors: macharia g. Front Immunol. 2021 Feb 18;12:609884. doi: 10.3389/fimmu.2021.609884. eCollection 2021. Front Immunol. 2021. PMID: 33679745 Free PMC article.
Breadth of CD8 T-cell mediated inhibition of replication of diverse HIV-1 transmitted-founder isolates correlates with the breadth of recognition within a comprehensive HIV-1 Gag, Nef, Env and Pol potential T-cell epitope (PTE) peptide set.
Hayes P, Fernandez N, Ochsenbauer C, Dalel J, Hare J, King D, Black L, Streatfield C, Kakarla V, Macharia G, Makinde J, Price M, Hunter E; IAVI protocol C investigators; Gilmour J. Hayes P, et al. Among authors: macharia g. PLoS One. 2021 Nov 17;16(11):e0260118. doi: 10.1371/journal.pone.0260118. eCollection 2021. PLoS One. 2021. PMID: 34788349 Free PMC article.
A Novel Sample Selection Approach to Aid the Identification of Factors That Correlate With the Control of HIV-1 Infection.
Makinde J, Nduati EW, Freni-Sterrantino A, Streatfield C, Kibirige C, Dalel J, Black SL, Hayes P, Macharia G, Hare J, McGowan E, Abel B, King D, Joseph S; IAVI Protocol C Investigators; Hunter E, Sanders EJ, Price M, Gilmour J. Makinde J, et al. Among authors: macharia g. Front Immunol. 2021 Mar 11;12:634832. doi: 10.3389/fimmu.2021.634832. eCollection 2021. Front Immunol. 2021. PMID: 33777023 Free PMC article.
Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection.
Macharia GN, Yue L, Staller E, Dilernia D, Wilkins D, Song H, McGowan E, King D, Fast P, Imami N, Price MA, Sanders EJ, Hunter E, Gilmour J. Macharia GN, et al. PLoS Pathog. 2020 Sep 4;16(9):e1008853. doi: 10.1371/journal.ppat.1008853. eCollection 2020 Sep. PLoS Pathog. 2020. PMID: 32886726 Free PMC article.
Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis.
Claiborne DT, Scully EP, Palmer CD, Prince JL, Macharia GN, Kopycinski J, Michelo CM, Wiener HW, Parker R, Nganou-Makamdop K, Douek D, Altfeld M, Gilmour J, Price MA, Tang J, Kilembe W, Allen SA, Hunter E. Claiborne DT, et al. PLoS Pathog. 2019 Aug 26;15(8):e1007981. doi: 10.1371/journal.ppat.1007981. eCollection 2019 Aug. PLoS Pathog. 2019. PMID: 31449552 Free PMC article.
Infection with HIV-1 subtype D among acutely infected Ugandans is associated with higher median concentration of cytokines compared to subtype A.
Kapaata A, Balinda SN, Hare J, Leonova O, Kikaire B, Egesa M, Lubyayi L, Macharia GN, Kamali A, Gilmour J, Bagaya B, Salazar-Gonzalez JF, Kaleebu P. Kapaata A, et al. Among authors: macharia gn. IJID Reg. 2022 Mar 10;3:89-95. doi: 10.1016/j.ijregi.2022.03.007. eCollection 2022 Jun. IJID Reg. 2022. PMID: 35755471 Free PMC article.
Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression.
Claiborne DT, Prince JL, Scully E, Macharia G, Micci L, Lawson B, Kopycinski J, Deymier MJ, Vanderford TH, Nganou-Makamdop K, Ende Z, Brooks K, Tang J, Yu T, Lakhi S, Kilembe W, Silvestri G, Douek D, Goepfert PA, Price MA, Allen SA, Paiardini M, Altfeld M, Gilmour J, Hunter E. Claiborne DT, et al. Among authors: macharia g. Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1480-9. doi: 10.1073/pnas.1421607112. Epub 2015 Feb 17. Proc Natl Acad Sci U S A. 2015. PMID: 25730868 Free PMC article.
26 results