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Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor.
Chen X, Li R, Pan Z, Qian C, Yang Y, You R, Zhao J, Liu P, Gao L, Li Z, Huang Q, Xu L, Tang J, Tian Q, Yao W, Hu L, Yan X, Zhou X, Wu Y, Deng K, Zhang Z, Qian Z, Chen Y, Ye L. Chen X, et al. Among authors: gao l. Cell Mol Immunol. 2020 Jun;17(6):647-649. doi: 10.1038/s41423-020-0426-7. Epub 2020 Apr 20. Cell Mol Immunol. 2020. PMID: 32313207 Free PMC article. No abstract available.
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19.
Chen X, Pan Z, Yue S, Yu F, Zhang J, Yang Y, Li R, Liu B, Yang X, Gao L, Li Z, Lin Y, Huang Q, Xu L, Tang J, Hu L, Zhao J, Liu P, Zhang G, Chen Y, Deng K, Ye L. Chen X, et al. Among authors: gao l. Signal Transduct Target Ther. 2020 Sep 2;5(1):180. doi: 10.1038/s41392-020-00301-9. Signal Transduct Target Ther. 2020. PMID: 32879307 Free PMC article.
A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD.
Wang X, Hu A, Chen X, Zhang Y, Yu F, Yue S, Li A, Zhang J, Pan Z, Yang Y, Lin Y, Gao L, Zhou J, Zhao J, Li F, Shi Y, Huang F, Yang X, Peng Y, Tu L, Zhang H, Zheng H, He J, Zhang H, Xu L, Huang Q, Zhu Y, Deng K, Ye L. Wang X, et al. Among authors: gao l. Signal Transduct Target Ther. 2022 Apr 5;7(1):114. doi: 10.1038/s41392-022-00954-8. Signal Transduct Target Ther. 2022. PMID: 35383141 Free PMC article.
Nasal Spray of Neutralizing Monoclonal Antibody 35B5 Confers Potential Prophylaxis Against Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Small-Scale Clinical Trial.
Lin Y, Yue S, Yang Y, Yang S, Pan Z, Yang X, Gao L, Zhou J, Li Z, Hu L, Tang J, Wu Q, Lei S, Tian Q, Wang Y, Hao Y, Xu L, Huang Q, Zhu B, Chen Y, Chen X, Ye L. Lin Y, et al. Among authors: gao l. Clin Infect Dis. 2023 Feb 8;76(3):e336-e341. doi: 10.1093/cid/ciac448. Clin Infect Dis. 2023. PMID: 35666466 Free PMC article. Clinical Trial.
The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes.
Huang Q, Wu X, Wang Z, Chen X, Wang L, Lu Y, Xiong D, Liu Q, Tian Y, Lin H, Guo J, Wen S, Dong W, Yang X, Yuan Y, Yue Z, Lei S, Wu Q, Ran L, Xie L, Wang Y, Gao L, Tian Q, Zhou X, Sun B, Xu L, Tang Z, Ye L. Huang Q, et al. Among authors: gao l. Cell. 2022 Oct 27;185(22):4049-4066.e25. doi: 10.1016/j.cell.2022.09.020. Epub 2022 Oct 7. Cell. 2022. PMID: 36208623 Free article.
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