Graf T - Search Results

1

A Comprehensive Assessment of All-Oleate Polysorbate 80: Free Fatty Acid Particle Formation, Interfacial Protection and Oxidative Degradation.

Doshi N, Giddings J, Luis L, Wu A, Ritchie K, Liu W, Chan W, Taing R, Chu J, Sreedhara A, Kannan A, Kei P, Shieh I, Graf T, Hu M. Doshi N, et al. Among authors: graf t. Pharm Res. 2021 Mar;38(3):531-548. doi: 10.1007/s11095-021-03021-z. Epub 2021 Mar 12. Pharm Res. 2021. PMID: 33713012

2

Identification and Characterization of Polysorbate-Degrading Enzymes in a Monoclonal Antibody Formulation.

Graf T, Tomlinson A, Yuk IH, Kufer R, Spensberger B, Falkenstein R, Shen A, Li H, Duan D, Liu W, Wohlrab S, Edelmann F, Leiss M. Graf T, et al. J Pharm Sci. 2021 Nov;110(11):3558-3567. doi: 10.1016/j.xphs.2021.06.033. Epub 2021 Jul 2. J Pharm Sci. 2021. PMID: 34224732

3

Monitoring polysorbate hydrolysis in biopharmaceuticals using a QC-ready free fatty acid quantification method.

Honemann MN, Wendler J, Graf T, Bathke A, Bell CH. Honemann MN, et al. Among authors: graf t. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 May 15;1116:1-8. doi: 10.1016/j.jchromb.2019.03.030. Epub 2019 Mar 26. J Chromatogr B Analyt Technol Biomed Life Sci. 2019. PMID: 30951966

4

Controlled polysorbate 20 hydrolysis - A new approach to assess the impact of polysorbate 20 degradation on biopharmaceutical product quality in shortened time.

Graf T, Abstiens K, Wedekind F, Elger C, Haindl M, Wurth C, Leiss M. Graf T, et al. Eur J Pharm Biopharm. 2020 Jul;152:318-326. doi: 10.1016/j.ejpb.2020.05.017. Epub 2020 May 20. Eur J Pharm Biopharm. 2020. PMID: 32445968

5

Simultaneous quantification of polysorbate 20 and poloxamer 188 in biopharmaceutical formulations using evaporative light scattering detection.

Paschen CA, Klemm D, Graf T, Kopf R, Pinto C, Müller C, Bell CH, Pfaff J. Paschen CA, et al. Among authors: graf t. J Pharm Biomed Anal. 2021 Jan 5;192:113640. doi: 10.1016/j.jpba.2020.113640. Epub 2020 Sep 16. J Pharm Biomed Anal. 2021. PMID: 33002754 Free article.

6

Recent advances in LC-MS based characterization of protein-based bio-therapeutics - mastering analytical challenges posed by the increasing format complexity.

Graf T, Heinrich K, Grunert I, Wegele H, Haberger M, Bulau P, Leiss M. Graf T, et al. J Pharm Biomed Anal. 2020 Jul 15;186:113251. doi: 10.1016/j.jpba.2020.113251. Epub 2020 Mar 10. J Pharm Biomed Anal. 2020. PMID: 32251978 Review.

7

Best practices on critical reagent characterization, qualification, and life cycle management for HCP immunoassays.

Graf T, Seisenberger C, Wiedmann M, Wohlrab S, Anderka O. Graf T, et al. Biotechnol Bioeng. 2021 Oct;118(10):3633-3639. doi: 10.1002/bit.27881. Epub 2021 Aug 20. Biotechnol Bioeng. 2021. PMID: 34241893 Review.

8

Questioning coverage values determined by 2D western blots: A critical study on the characterization of anti-HCP ELISA reagents.

Seisenberger C, Graf T, Haindl M, Wegele H, Wiedmann M, Wohlrab S. Seisenberger C, et al. Among authors: graf t. Biotechnol Bioeng. 2021 Mar;118(3):1116-1126. doi: 10.1002/bit.27635. Epub 2020 Dec 4. Biotechnol Bioeng. 2021. PMID: 33241851

9

Monitoring modifications in biopharmaceuticals: Toolbox for a generic and robust high-throughput quantification method.

Bauer LG, Hoelterhoff S, Graf T, Bell C, Bathke A. Bauer LG, et al. Among authors: graf t. J Chromatogr B Analyt Technol Biomed Life Sci. 2020 May 11;1148:122134. doi: 10.1016/j.jchromb.2020.122134. Online ahead of print. J Chromatogr B Analyt Technol Biomed Life Sci. 2020. PMID: 32422530

10

Toward optimal clearance: A universal affinity-based mass spectrometry approach for comprehensive ELISA reagent coverage evaluation and HCP hitchhiker analysis.

Seisenberger C, Graf T, Haindl M, Wegele H, Wiedmann M, Wohlrab S. Seisenberger C, et al. Among authors: graf t. Biotechnol Prog. 2022 May;38(3):e3244. doi: 10.1002/btpr.3244. Epub 2022 Mar 11. Biotechnol Prog. 2022. PMID: 35150475

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