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Long QT Syndrome KCNH2 Variant Induces hERG1a/1b Subunit Imbalance in Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Feng L, Zhang J, Lee C, Kim G, Liu F, Petersen AJ, Lim E, Anderson CL, Orland KM, Robertson GA, Eckhardt LL, January CT, Kamp TJ. Feng L, et al. Among authors: robertson ga. Circ Arrhythm Electrophysiol. 2021 Apr;14(4):e009343. doi: 10.1161/CIRCEP.120.009343. Epub 2021 Mar 17. Circ Arrhythm Electrophysiol. 2021. PMID: 33729832 Free PMC article.
Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I(Kr).
Rajamani S, Anderson CL, Valdivia CR, Eckhardt LL, Foell JD, Robertson GA, Kamp TJ, Makielski JC, Anson BD, January CT. Rajamani S, et al. Among authors: robertson ga. Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1278-88. doi: 10.1152/ajpheart.00777.2005. Epub 2005 Oct 14. Am J Physiol Heart Circ Physiol. 2006. PMID: 16227340 Free article.
hERG 1b is critical for human cardiac repolarization.
Jones DK, Liu F, Vaidyanathan R, Eckhardt LL, Trudeau MC, Robertson GA. Jones DK, et al. Among authors: robertson ga. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):18073-7. doi: 10.1073/pnas.1414945111. Epub 2014 Dec 1. Proc Natl Acad Sci U S A. 2014. PMID: 25453103 Free PMC article.
141 results