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Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes.
Ravindra NG, Alfajaro MM, Gasque V, Huston NC, Wan H, Szigeti-Buck K, Yasumoto Y, Greaney AM, Habet V, Chow RD, Chen JS, Wei J, Filler RB, Wang B, Wang G, Niklason LE, Montgomery RR, Eisenbarth SC, Chen S, Williams A, Iwasaki A, Horvath TL, Foxman EF, Pierce RW, Pyle AM, van Dijk D, Wilen CB. Ravindra NG, et al. Among authors: niklason le. PLoS Biol. 2021 Mar 17;19(3):e3001143. doi: 10.1371/journal.pbio.3001143. eCollection 2021 Mar. PLoS Biol. 2021. PMID: 33730024 Free PMC article.
Single-cell connectomic analysis of adult mammalian lungs.
Raredon MSB, Adams TS, Suhail Y, Schupp JC, Poli S, Neumark N, Leiby KL, Greaney AM, Yuan Y, Horien C, Linderman G, Engler AJ, Boffa DJ, Kluger Y, Rosas IO, Levchenko A, Kaminski N, Niklason LE. Raredon MSB, et al. Among authors: niklason le. Sci Adv. 2019 Dec 4;5(12):eaaw3851. doi: 10.1126/sciadv.aaw3851. eCollection 2019 Dec. Sci Adv. 2019. PMID: 31840053 Free PMC article.
Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung.
Schupp JC, Adams TS, Cosme C Jr, Raredon MSB, Yuan Y, Omote N, Poli S, Chioccioli M, Rose KA, Manning EP, Sauler M, DeIuliis G, Ahangari F, Neumark N, Habermann AC, Gutierrez AJ, Bui LT, Lafyatis R, Pierce RW, Meyer KB, Nawijn MC, Teichmann SA, Banovich NE, Kropski JA, Niklason LE, Pe'er D, Yan X, Homer RJ, Rosas IO, Kaminski N. Schupp JC, et al. Among authors: niklason le. Circulation. 2021 Jul 27;144(4):286-302. doi: 10.1161/CIRCULATIONAHA.120.052318. Epub 2021 May 25. Circulation. 2021. PMID: 34030460 Free PMC article.
Microvascular fluid flow in ex vivo and engineered lungs.
Raredon MSB, Engler AJ, Yuan Y, Greaney AM, Niklason LE. Raredon MSB, et al. Among authors: niklason le. J Appl Physiol (1985). 2021 Nov 1;131(5):1444-1459. doi: 10.1152/japplphysiol.00286.2020. Epub 2021 Sep 23. J Appl Physiol (1985). 2021. PMID: 34554016 Free PMC article.
A Pulmonary Vascular Model From Endothelialized Whole Organ Scaffolds.
Yuan Y, Leiby KL, Greaney AM, Raredon MSB, Qian H, Schupp JC, Engler AJ, Baevova P, Adams TS, Kural MH, Wang J, Obata T, Yoder MC, Kaminski N, Niklason LE. Yuan Y, et al. Among authors: niklason le. Front Bioeng Biotechnol. 2021 Nov 19;9:760309. doi: 10.3389/fbioe.2021.760309. eCollection 2021. Front Bioeng Biotechnol. 2021. PMID: 34869270 Free PMC article.
Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids.
Cakir B, Tanaka Y, Kiral FR, Xiang Y, Dagliyan O, Wang J, Lee M, Greaney AM, Yang WS, duBoulay C, Kural MH, Patterson B, Zhong M, Kim J, Bai Y, Min W, Niklason LE, Patra P, Park IH. Cakir B, et al. Among authors: niklason le. Nat Commun. 2022 Jan 20;13(1):430. doi: 10.1038/s41467-022-28043-y. Nat Commun. 2022. PMID: 35058453 Free PMC article.
Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19.
Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K; Yale IMPACT Research Team; Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS. Unterman A, et al. Among authors: niklason le. Nat Commun. 2022 Jan 21;13(1):440. doi: 10.1038/s41467-021-27716-4. Nat Commun. 2022. PMID: 35064122 Free PMC article.
202 results