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Epigenetic inactivation of ERF reactivates γ-globin expression in β-thalassemia.
Bao X, Zhang X, Wang L, Wang Z, Huang J, Zhang Q, Ye Y, Liu Y, Chen D, Zuo Y, Liu Q, Xu P, Huang B, Fang J, Lao J, Feng X, Li Y, Kurita R, Nakamura Y, Yu W, Ju C, Huang C, Mohandas N, Li D, Zhao C, Xu X. Bao X, et al. Among authors: nakamura y. Am J Hum Genet. 2021 Apr 1;108(4):709-721. doi: 10.1016/j.ajhg.2021.03.005. Epub 2021 Mar 17. Am J Hum Genet. 2021. PMID: 33735615 Free PMC article.
GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex.
Liang Y, Zhang X, Liu Y, Wang L, Ye Y, Tan X, Pu J, Zhang Q, Bao X, Wei X, Li D, Kurita R, Nakamura Y, Li D, Xu X. Liang Y, et al. Among authors: nakamura y. Br J Haematol. 2021 Jun;193(6):1220-1227. doi: 10.1111/bjh.17511. Epub 2021 May 17. Br J Haematol. 2021. PMID: 33997955
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