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DNA-Model-Based Design and Execution of Some Fused Benzodiazepine Hybrid Payloads for Antibody-Drug Conjugate Modality.
Sivaprakasam P, McDonald I, Iwuagwu C, Chowdari NS, Peese KM, Langley DR, Cheng H, Luzung MR, Schmidt MA, Zheng B, Tan Y, Cho P, Rakshit S, Lakshminarasimhan T, Guturi S, Kanagavel K, Kanusu U, Niyogi AG, Sidhar S, Vaidyanathan R, Eastgate MD, Kotapati S, Deshpande M, Pan C, Cardarelli PM, Xie C, Rao C, Holder P, Sarma G, Vite G, Gangwar S. Sivaprakasam P, et al. Among authors: vaidyanathan r. ACS Med Chem Lett. 2021 Feb 10;12(3):404-412. doi: 10.1021/acsmedchemlett.0c00578. eCollection 2021 Mar 11. ACS Med Chem Lett. 2021. PMID: 33738068 Free PMC article.
Zinc Acetate-Promoted Buchwald-Hartwig Couplings of Heteroaromatic Amines.
Ayothiraman R, Rangaswamy S, Maity P, Simmons EM, Beutner GL, Janey J, Treitler DS, Eastgate MD, Vaidyanathan R. Ayothiraman R, et al. Among authors: vaidyanathan r. J Org Chem. 2017 Jul 21;82(14):7420-7427. doi: 10.1021/acs.joc.7b01101. Epub 2017 Jul 5. J Org Chem. 2017. PMID: 28677970
Development of a Practical Synthesis of the 8-FDC Fragment of OPC-167832.
Gopalsamuthiram V, Ho DB, Peck CL, Natarajan V, Agrawal T, Burns JM, Bachert J, Cook DW, Stringham RW, Nelson R, Ahmad S, Gupton BF, Snead DR, McQuade DT, Vaidyanathan R, Donsbach K, Sieber JD. Gopalsamuthiram V, et al. Among authors: vaidyanathan r. ACS Omega. 2022 Feb 18;7(8):7223-7228. doi: 10.1021/acsomega.1c06996. eCollection 2022 Mar 1. ACS Omega. 2022. PMID: 35252712 Free PMC article.
Mild and efficient DBU-catalyzed amidation of cyanoacetates.
Price KE, Larrivée-Aboussafy C, Lillie BM, McLaughlin RW, Mustakis J, Hettenbach KW, Hawkins JM, Vaidyanathan R. Price KE, et al. Among authors: vaidyanathan r. Org Lett. 2009 May 7;11(9):2003-6. doi: 10.1021/ol900435t. Org Lett. 2009. PMID: 19341310
DBU catalysis of N,N'-carbonyldiimidazole-mediated amidations.
Larrivée-Aboussafy C, Jones BP, Price KE, Hardink MA, McLaughlin RW, Lillie BM, Hawkins JM, Vaidyanathan R. Larrivée-Aboussafy C, et al. Among authors: vaidyanathan r. Org Lett. 2010 Jan 15;12(2):324-7. doi: 10.1021/ol9026599. Org Lett. 2010. PMID: 20014771
192 results