Cierpicki T - Search Results

1

EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma.

Jiménez JA, Apfelbaum AA, Hawkins AG, Svoboda LK, Kumar A, Ruiz RO, Garcia AX, Haarer E, Nwosu ZC, Bradin J, Purohit T, Chen D, Cierpicki T, Grembecka J, Lyssiotis CA, Lawlor ER. Jiménez JA, et al. Among authors: cierpicki t. Mol Cancer Res. 2021 Jul;19(7):1182-1195. doi: 10.1158/1541-7786.MCR-20-0679. Epub 2021 Mar 19. Mol Cancer Res. 2021. PMID: 33741715 Free PMC article.

2

A lipopeptidomimetic of transcriptional activation domains selectively disrupts Med25 PPIs.

Pattelli ON, Valdivia EM, Beyersdorf MS, Regan CS, Rivas M, Merajver SD, Cierpicki T, Mapp AK. Pattelli ON, et al. Among authors: cierpicki t. bioRxiv [Preprint]. 2023 Mar 25:2023.03.24.534168. doi: 10.1101/2023.03.24.534168. bioRxiv. 2023. Update in: Angew Chem Int Ed Engl. 2024 May 21;63(21):e202400781. doi: 10.1002/anie.202400781 PMID: 36993479 Free PMC article. Updated. Preprint.

3

MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.

Erfurth FE, Popovic R, Grembecka J, Cierpicki T, Theisler C, Xia ZB, Stuart T, Diaz MO, Bushweller JH, Zeleznik-Le NJ. Erfurth FE, et al. Among authors: cierpicki t. Proc Natl Acad Sci U S A. 2008 May 27;105(21):7517-22. doi: 10.1073/pnas.0800090105. Epub 2008 May 15. Proc Natl Acad Sci U S A. 2008. PMID: 18483194 Free PMC article.

4

Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.

Cierpicki T, Risner LE, Grembecka J, Lukasik SM, Popovic R, Omonkowska M, Shultis DD, Zeleznik-Le NJ, Bushweller JH. Cierpicki T, et al. Nat Struct Mol Biol. 2010 Jan;17(1):62-8. doi: 10.1038/nsmb.1714. Epub 2009 Dec 13. Nat Struct Mol Biol. 2010. PMID: 20010842 Free PMC article.

5

Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias.

Grembecka J, Belcher AM, Hartley T, Cierpicki T. Grembecka J, et al. Among authors: cierpicki t. J Biol Chem. 2010 Dec 24;285(52):40690-8. doi: 10.1074/jbc.M110.172783. Epub 2010 Oct 20. J Biol Chem. 2010. PMID: 20961854 Free PMC article.

6

Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein.

Murai MJ, Chruszcz M, Reddy G, Grembecka J, Cierpicki T. Murai MJ, et al. Among authors: cierpicki t. J Biol Chem. 2011 Sep 9;286(36):31742-8. doi: 10.1074/jbc.M111.258186. Epub 2011 Jul 13. J Biol Chem. 2011. PMID: 21757704 Free PMC article.

7

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia.

Grembecka J, He S, Shi A, Purohit T, Muntean AG, Sorenson RJ, Showalter HD, Murai MJ, Belcher AM, Hartley T, Hess JL, Cierpicki T. Grembecka J, et al. Among authors: cierpicki t. Nat Chem Biol. 2012 Jan 29;8(3):277-84. doi: 10.1038/nchembio.773. Nat Chem Biol. 2012. PMID: 22286128 Free PMC article.

8

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

Shi A, Murai MJ, He S, Lund G, Hartley T, Purohit T, Reddy G, Chruszcz M, Grembecka J, Cierpicki T. Shi A, et al. Among authors: cierpicki t. Blood. 2012 Nov 29;120(23):4461-9. doi: 10.1182/blood-2012-05-429274. Epub 2012 Aug 30. Blood. 2012. PMID: 22936661 Free PMC article.

9

Detection of disordered regions in globular proteins using ¹³C-detected NMR.

Gray FL, Murai MJ, Grembecka J, Cierpicki T. Gray FL, et al. Among authors: cierpicki t. Protein Sci. 2012 Dec;21(12):1954-60. doi: 10.1002/pro.2174. Protein Sci. 2012. PMID: 23047544 Free PMC article.

10

Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias.

Rakowski LA, Garagiola DD, Li CM, Decker M, Caruso S, Jones M, Kuick R, Cierpicki T, Maillard I, Chiang MY. Rakowski LA, et al. Among authors: cierpicki t. Cancer Res. 2013 Jan 15;73(2):930-41. doi: 10.1158/0008-5472.CAN-12-1389. Epub 2012 Nov 16. Cancer Res. 2013. PMID: 23161489 Free PMC article.

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