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Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions.
Flynn RA, Belk JA, Qi Y, Yasumoto Y, Wei J, Alfajaro MM, Shi Q, Mumbach MR, Limaye A, DeWeirdt PC, Schmitz CO, Parker KR, Woo E, Chang HY, Horvath TL, Carette JE, Bertozzi CR, Wilen CB, Satpathy AT. Flynn RA, et al. Among authors: carette je. Cell. 2021 Apr 29;184(9):2394-2411.e16. doi: 10.1016/j.cell.2021.03.012. Epub 2021 Mar 11. Cell. 2021. PMID: 33743211 Free PMC article.
A CRISPR toolbox to study virus-host interactions.
Puschnik AS, Majzoub K, Ooi YS, Carette JE. Puschnik AS, et al. Among authors: carette je. Nat Rev Microbiol. 2017 Jun;15(6):351-364. doi: 10.1038/nrmicro.2017.29. Epub 2017 Apr 19. Nat Rev Microbiol. 2017. PMID: 28420884 Free PMC article. Review.
An RNA-centric dissection of host complexes controlling flavivirus infection.
Ooi YS, Majzoub K, Flynn RA, Mata MA, Diep J, Li JK, van Buuren N, Rumachik N, Johnson AG, Puschnik AS, Marceau CD, Mlera L, Grabowski JM, Kirkegaard K, Bloom ME, Sarnow P, Bertozzi CR, Carette JE. Ooi YS, et al. Among authors: carette je. Nat Microbiol. 2019 Dec;4(12):2369-2382. doi: 10.1038/s41564-019-0518-2. Epub 2019 Aug 5. Nat Microbiol. 2019. PMID: 31384002 Free PMC article.
A memory of eS25 loss drives resistance phenotypes.
Johnson AG, Flynn RA, Lapointe CP, Ooi YS, Zhao ML, Richards CM, Qiao W, Yamada SB, Couthouis J, Gitler AD, Carette JE, Puglisi JD. Johnson AG, et al. Among authors: carette je. Nucleic Acids Res. 2020 Jul 27;48(13):7279-7297. doi: 10.1093/nar/gkaa444. Nucleic Acids Res. 2020. PMID: 32463448 Free PMC article.
Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection.
Flynn RA, Belk JA, Qi Y, Yasumoto Y, Schmitz CO, Mumbach MR, Limaye A, Wei J, Alfajaro MM, Parker KR, Chang HY, Horvath TL, Carette JE, Bertozzi C, Wilen CB, Satpathy AT. Flynn RA, et al. Among authors: carette je. bioRxiv [Preprint]. 2020 Oct 6:2020.10.06.327445. doi: 10.1101/2020.10.06.327445. bioRxiv. 2020. Update in: Cell. 2021 Apr 29;184(9):2394-2411.e16. doi: 10.1016/j.cell.2021.03.012 PMID: 33052334 Free PMC article. Updated. Preprint.
Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses.
Wang R, Simoneau CR, Kulsuptrakul J, Bouhaddou M, Travisano KA, Hayashi JM, Carlson-Stevermer J, Zengel JR, Richards CM, Fozouni P, Oki J, Rodriguez L, Joehnk B, Walcott K, Holden K, Sil A, Carette JE, Krogan NJ, Ott M, Puschnik AS. Wang R, et al. Among authors: carette je. Cell. 2021 Jan 7;184(1):106-119.e14. doi: 10.1016/j.cell.2020.12.004. Epub 2020 Dec 9. Cell. 2021. PMID: 33333024 Free PMC article.
Small RNAs are modified with N-glycans and displayed on the surface of living cells.
Flynn RA, Pedram K, Malaker SA, Batista PJ, Smith BAH, Johnson AG, George BM, Majzoub K, Villalta PW, Carette JE, Bertozzi CR. Flynn RA, et al. Among authors: carette je. Cell. 2021 Jun 10;184(12):3109-3124.e22. doi: 10.1016/j.cell.2021.04.023. Epub 2021 May 17. Cell. 2021. PMID: 34004145 Free PMC article.
Loquacious modulates flaviviral RNA replication in mosquito cells.
Shivaprasad S, Weng KF, Ooi YS, Belk J, Carette JE, Flynn R, Sarnow P. Shivaprasad S, et al. Among authors: carette je. PLoS Pathog. 2022 Apr 28;18(4):e1010163. doi: 10.1371/journal.ppat.1010163. eCollection 2022 Apr. PLoS Pathog. 2022. PMID: 35482886 Free PMC article.
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.
Biering SB, Sarnik SA, Wang E, Zengel JR, Leist SR, Schäfer A, Sathyan V, Hawkins P, Okuda K, Tau C, Jangid AR, Duffy CV, Wei J, Gilmore RC, Alfajaro MM, Strine MS, Nguyenla X, Van Dis E, Catamura C, Yamashiro LH, Belk JA, Begeman A, Stark JC, Shon DJ, Fox DM, Ezzatpour S, Huang E, Olegario N, Rustagi A, Volmer AS, Livraghi-Butrico A, Wehri E, Behringer RR, Cheon DJ, Schaletzky J, Aguilar HC, Puschnik AS, Button B, Pinsky BA, Blish CA, Baric RS, O'Neal WK, Bertozzi CR, Wilen CB, Boucher RC, Carette JE, Stanley SA, Harris E, Konermann S, Hsu PD. Biering SB, et al. Among authors: carette je. Nat Genet. 2022 Aug;54(8):1078-1089. doi: 10.1038/s41588-022-01131-x. Epub 2022 Jul 25. Nat Genet. 2022. PMID: 35879412 Free PMC article.
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.
Richards CM, Jabs S, Qiao W, Varanese LD, Schweizer M, Mosen PR, Riley NM, Klüssendorf M, Zengel JR, Flynn RA, Rustagi A, Widen JC, Peters CE, Ooi YS, Xie X, Shi PY, Bartenschlager R, Puschnik AS, Bogyo M, Bertozzi CR, Blish CA, Winter D, Nagamine CM, Braulke T, Carette JE. Richards CM, et al. Among authors: carette je. Science. 2022 Oct 7;378(6615):eabn5648. doi: 10.1126/science.abn5648. Epub 2022 Oct 7. Science. 2022. PMID: 36074821 Free PMC article.
116 results