Hughes JME - Search Results

1

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer.

Quiroz RV, Reutershan MH, Schneider SE, Sloman D, Lacey BM, Swalm BM, Yeung CS, Gibeau C, Spellman DS, Rankic DA, Chen D, Witter D, Linn D, Munsell E, Feng G, Xu H, Hughes JME, Lim J, Saurí J, Geddes K, Wan M, Mansueto MS, Follmer NE, Fier PS, Siliphaivanh P, Daublain P, Palte RL, Hayes RP, Lee S, Kawamura S, Silverman S, Sanyal S, Henderson TJ, Ye Y, Gao Y, Nicholson B, Machacek MR. Quiroz RV, et al. Among authors: hughes jme. J Med Chem. 2021 Apr 8;64(7):3911-3939. doi: 10.1021/acs.jmedchem.0c02083. Epub 2021 Mar 23. J Med Chem. 2021. PMID: 33755451

2

Desulfonylative Arylation of Redox-Active Alkyl Sulfones with Aryl Bromides.

Hughes JME, Fier PS. Hughes JME, et al. Org Lett. 2019 Jul 19;21(14):5650-5654. doi: 10.1021/acs.orglett.9b01987. Epub 2019 Jul 5. Org Lett. 2019. PMID: 31273985

3

Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy.

Skudlarek JW, Cooke AJ, Mitchell HJ, Babaoglu K, Shaw AW, Tong L, Nomland AB, Labroli M, Sha D, Mulhearn JJ, Wu C, Li SW, Beshore DC, Hughes JME, Jouffroy M, Wang H, Balibar CJ, Painter RE, Shen P, Lange HS, Ishchenko A, Chen YT, Klein DJ, Tracy RW, Miller RR, Cabalu TD, Wu Z, Leithead A, Scapin G, Hruza AW, Dzhekieva L, Bukhtiyarova M, Homsher MF, Xu M, Bahnck-Teets C, McKenney D, Buevich AV, Liu J, Zhang LK, Meng T, Kelly T, DiNunzio E, Soisson S, Cheng RKY, Hennig M, Raheem I, Walker SS. Skudlarek JW, et al. Among authors: hughes jme. J Med Chem. 2024 Sep 12;67(17):15620-15675. doi: 10.1021/acs.jmedchem.4c01277. Epub 2024 Aug 22. J Med Chem. 2024. PMID: 39172133

4

An intramolecular coupling approach to alkyl bioisosteres for the synthesis of multisubstituted bicycloalkyl boronates.

Yang Y, Tsien J, Hughes JME, Peters BK, Merchant RR, Qin T. Yang Y, et al. Among authors: hughes jme. Nat Chem. 2021 Oct;13(10):950-955. doi: 10.1038/s41557-021-00786-z. Epub 2021 Sep 28. Nat Chem. 2021. PMID: 34584254 Free PMC article.

5

Nickel-Catalyzed Reductive Arylation of Redox Active Esters for the Synthesis of α-Aryl Nitriles: Investigation of a Chlorosilane Additive.

Michel NWM, Gabbey AL, Edjoc RK, Fagbola E, Hughes JME, Campeau LC, Rousseaux SAL. Michel NWM, et al. Among authors: hughes jme. J Org Chem. 2024 Nov 15;89(22):16161-16169. doi: 10.1021/acs.joc.3c02354. Epub 2024 Jan 10. J Org Chem. 2024. PMID: 38197128

6

Asymmetric Synthesis of Tertiary and Secondary Cyclopropyl Boronates via Cyclopropanation of Enantioenriched Alkenyl Boronic Esters.

Gutiérrez-Bonet Á, Popov S, Emmert MH, Hughes JME, Nolting AF, Ruccolo S, Wang Y. Gutiérrez-Bonet Á, et al. Among authors: hughes jme. Org Lett. 2022 May 20;24(19):3455-3460. doi: 10.1021/acs.orglett.2c01018. Epub 2022 May 11. Org Lett. 2022. PMID: 35544734

7

Programmable late-stage functionalization of bridge-substituted bicyclo[1.1.1]pentane bis-boronates.

Yang Y, Tsien J, Dykstra R, Chen SJ, Wang JB, Merchant RR, Hughes JME, Peters BK, Gutierrez O, Qin T. Yang Y, et al. Among authors: hughes jme. Nat Chem. 2024 Feb;16(2):285-293. doi: 10.1038/s41557-023-01342-7. Epub 2023 Oct 26. Nat Chem. 2024. PMID: 37884667 Free PMC article.

8

Enantioenriched BCP Benzylamine Synthesis via Metal Hydride Hydrogen Atom Transfer/Sulfinimine Addition to [1.1.1]Propellane.

Shelp R, Merchant RR, Hughes JME, Walsh PJ. Shelp R, et al. Among authors: hughes jme. Org Lett. 2022 Jan 14;24(1):110-114. doi: 10.1021/acs.orglett.1c03681. Epub 2021 Dec 15. Org Lett. 2022. PMID: 34908426

9

Alkyl sulfinates as cross-coupling partners for programmable and stereospecific installation of C(sp³) bioisosteres.

Zhou M, Tsien J, Dykstra R, Hughes JME, Peters BK, Merchant RR, Gutierrez O, Qin T. Zhou M, et al. Among authors: hughes jme. Nat Chem. 2023 Apr;15(4):550-559. doi: 10.1038/s41557-023-01150-z. Epub 2023 Mar 2. Nat Chem. 2023. PMID: 36864142 Free PMC article.

10

Uncanonical Semireduction of Quinolines and Isoquinolines via Regioselective HAT-Promoted Hydrosilylation.

Hu C, Vo C, Merchant RR, Chen SJ, Hughes JME, Peters BK, Qin T. Hu C, et al. Among authors: hughes jme. J Am Chem Soc. 2023 Jan 11;145(1):25-31. doi: 10.1021/jacs.2c11664. Epub 2022 Dec 22. J Am Chem Soc. 2023. PMID: 36548026 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

17 results

Search Page

Filters