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The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways.
Vallelian F, Pimenova T, Pereira CP, Abraham B, Mikolajczyk MG, Schoedon G, Zenobi R, Alayash AI, Buehler PW, Schaer DJ. Vallelian F, et al. Among authors: buehler pw. Free Radic Biol Med. 2008 Oct 15;45(8):1150-8. doi: 10.1016/j.freeradbiomed.2008.07.013. Epub 2008 Jul 27. Free Radic Biol Med. 2008. PMID: 18708138
Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats.
Irwin D, Buehler PW, Alayash AI, Jia Y, Bonventura J, Foreman B, White M, Jacobs R, Piteo B, TissotvanPatot MC, Hamilton KL, Gotshall RW. Irwin D, et al. Among authors: buehler pw. Am J Respir Cell Mol Biol. 2010 Feb;42(2):200-9. doi: 10.1165/rcmb.2008-0364OC. Epub 2009 Apr 24. Am J Respir Cell Mol Biol. 2010. PMID: 19395680 Free PMC article.
Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.
Boretti FS, Buehler PW, D'Agnillo F, Kluge K, Glaus T, Butt OI, Jia Y, Goede J, Pereira CP, Maggiorini M, Schoedon G, Alayash AI, Schaer DJ. Boretti FS, et al. Among authors: buehler pw. J Clin Invest. 2009 Aug;119(8):2271-80. doi: 10.1172/JCI39115. Epub 2009 Jul 20. J Clin Invest. 2009. PMID: 19620788 Free PMC article.
141 results