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Page 1
Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.
Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC. Buehler PW, et al. Among authors: irwin dc. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L312-26. doi: 10.1152/ajplung.00074.2012. Epub 2012 Jun 22. Am J Physiol Lung Cell Mol Physiol. 2012. PMID: 22728465 Free PMC article.
Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration.
Irwin DC, Baek JH, Hassell K, Nuss R, Eigenberger P, Lisk C, Loomis Z, Maltzahn J, Stenmark KR, Nozik-Grayck E, Buehler PW. Irwin DC, et al. Free Radic Biol Med. 2015 May;82:50-62. doi: 10.1016/j.freeradbiomed.2015.01.012. Epub 2015 Feb 2. Free Radic Biol Med. 2015. PMID: 25656991 Free PMC article.
Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis.
Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ. Schaer CA, et al. Among authors: irwin dc. Am J Respir Crit Care Med. 2016 May 15;193(10):1111-22. doi: 10.1164/rccm.201510-2058OC. Am J Respir Crit Care Med. 2016. PMID: 26694989 Free PMC article.
Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation.
Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark K, Buehler P, Irwin DC. Loomis Z, et al. Among authors: irwin dc. PLoS One. 2017 Feb 2;12(2):e0171219. doi: 10.1371/journal.pone.0171219. eCollection 2017. PLoS One. 2017. PMID: 28152051 Free PMC article.
Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia.
Ferguson SK, Redinius K, Yalamanoglu A, Harral JW, Hyen Baek J, Pak D, Loomis Z, Hassell D, Eigenberger P, Nozik-Grayck E, Nuss R, Hassell K, Stenmark KR, Buehler PW, Irwin DC. Ferguson SK, et al. Among authors: irwin dc. J Physiol. 2019 Feb;597(4):1073-1085. doi: 10.1113/JP275810. Epub 2018 Aug 25. J Physiol. 2019. PMID: 29931797 Free PMC article.
Attenuation of human hypoxic pulmonary vasoconstriction by acetazolamide and methazolamide.
Boulet LM, Teppema LJ, Hackett HK, Dominelli PB, Cheyne WS, Dominelli GS, Irwin DC, Buehler PW, Baek JH, Swenson ER, Foster GE. Boulet LM, et al. Among authors: irwin dc. J Appl Physiol (1985). 2018 Dec 1;125(6):1795-1803. doi: 10.1152/japplphysiol.00509.2018. Epub 2018 Sep 20. J Appl Physiol (1985). 2018. PMID: 30236048 Free article.
79 results