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Verifying the role of 3-hydroxy of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6β-[(4'-pyridyl) carboxamido]morphinan derivatives via their binding affinity and selectivity profiles on opioid receptors.
Huang B, Gunta R, Wang H, Li M, Cao D, Mendez RE, Gillespie JC, Chen C, Huang LM, Liu-Chen LY, Selley DE, Zhang Y. Huang B, et al. Among authors: gillespie jc. Bioorg Chem. 2021 Apr;109:104702. doi: 10.1016/j.bioorg.2021.104702. Epub 2021 Feb 9. Bioorg Chem. 2021. PMID: 33631465 Free PMC article.
Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment.
Huang B, Li M, Klongkumnuankarn P, Mendez RE, Gillespie JC, Stevens DL, Dewey WL, Selley DE, Zhang Y. Huang B, et al. Among authors: gillespie jc. J Med Chem. 2022 Mar 24;65(6):4991-5003. doi: 10.1021/acs.jmedchem.1c02185. Epub 2022 Mar 8. J Med Chem. 2022. PMID: 35255683 Free PMC article.
Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists.
Pagare PP, Li M, Zheng Y, Kulkarni AS, Obeng S, Huang B, Ruiz C, Gillespie JC, Mendez RE, Stevens DL, Poklis JL, Halquist MS, Dewey WL, Selley DE, Zhang Y. Pagare PP, et al. Among authors: gillespie jc. J Med Chem. 2022 Mar 24;65(6):5095-5112. doi: 10.1021/acs.jmedchem.2c00087. Epub 2022 Mar 7. J Med Chem. 2022. PMID: 35255685 Free PMC article.
Dissociation between the anti-allodynic effects of fingolimod (FTY720) and desensitization of S1P1 receptor-mediated G-protein activation in a mouse model of sciatic nerve injury.
Pondelick AM, Moncayo LV, Donvito G, McLane VD, Gillespie JC, Hauser KF, Spiegel S, Lichtman AH, Sim-Selley LJ, Selley DE. Pondelick AM, et al. Among authors: gillespie jc. Neuropharmacology. 2024 Dec 15;261:110165. doi: 10.1016/j.neuropharm.2024.110165. Epub 2024 Sep 18. Neuropharmacology. 2024. PMID: 39303855
17 results