Laufer S - Search Results

1

Synthesis, Characterization, and in vivo Distribution of Intracellular Delivered Macrolide Short-Chain Fatty Acid Derivatives.

Straß S, Schwamborn A, Keppler M, Cloos N, Guezguez J, Guse JH, Burnet M, Laufer S. Straß S, et al. Among authors: laufer s. ChemMedChem. 2021 Jul 20;16(14):2254-2269. doi: 10.1002/cmdc.202100139. Epub 2021 May 11. ChemMedChem. 2021. PMID: 33787081

2

Are MAP kinases drug targets? Yes, but difficult ones.

Margutti S, Laufer SA. Margutti S, et al. Among authors: laufer sa. ChemMedChem. 2007 Aug;2(8):1116-40. doi: 10.1002/cmdc.200600271. ChemMedChem. 2007. PMID: 17541990 Review.

3

2-Acylaminopyridin-4-ylimidazoles as p38 MAP kinase inhibitors: Design, synthesis, and biological and metabolic evaluations.

Ziegler K, Hauser DR, Unger A, Albrecht W, Laufer SA. Ziegler K, et al. ChemMedChem. 2009 Nov;4(11):1939-48. doi: 10.1002/cmdc.200900242. ChemMedChem. 2009. PMID: 19731280

4

Synthesis and biological testing of N-aminoimidazole-based p38alpha MAP kinase inhibitors.

Bracht C, Hauser DR, Schattel V, Albrecht W, Laufer SA. Bracht C, et al. ChemMedChem. 2010 Jul 5;5(7):1134-42. doi: 10.1002/cmdc.201000114. ChemMedChem. 2010. PMID: 20473979

5

Design and synthesis of tricyclic JAK3 inhibitors with picomolar affinities as novel molecular probes.

Gehringer M, Pfaffenrot E, Bauer S, Laufer SA. Gehringer M, et al. Among authors: laufer sa. ChemMedChem. 2014 Feb;9(2):277-81. doi: 10.1002/cmdc.201300520. Epub 2014 Jan 8. ChemMedChem. 2014. PMID: 24403205

6

Novel hinge-binding motifs for Janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres.

Gehringer M, Forster M, Pfaffenrot E, Bauer SM, Laufer SA. Gehringer M, et al. ChemMedChem. 2014 Nov;9(11):2516-27. doi: 10.1002/cmdc.201402252. Epub 2014 Aug 19. ChemMedChem. 2014. PMID: 25139757

7

The European Federation for Medicinal Chemistry (EFMC) Best Practice Initiative: Validating Chemical Probes.

Quancard J, Cox B, Finsinger D, Guéret SM, Hartung IV, Koolman HF, Messinger J, Sbardella G, Laufer S. Quancard J, et al. Among authors: laufer s. ChemMedChem. 2020 Dec 15;15(24):2388-2390. doi: 10.1002/cmdc.202000597. Epub 2020 Sep 3. ChemMedChem. 2020. PMID: 32881363

8

The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Phenotypic Drug Discovery.

Quancard J, Bach A, Cox B, Craft R, Finsinger D, Guéret SM, Hartung IV, Laufer S, Messinger J, Sbardella G, Koolman HF. Quancard J, et al. Among authors: laufer s. ChemMedChem. 2021 Jun 7;16(11):1736-1739. doi: 10.1002/cmdc.202100041. Epub 2021 Apr 7. ChemMedChem. 2021. PMID: 33825353

9

Design and Synthesis of Highly Selective Brain Penetrant p38α Mitogen-Activated Protein Kinase Inhibitors.

Tormählen NM, Martorelli M, Kuhn A, Maier F, Guezguez J, Burnet M, Albrecht W, Laufer SA, Koch P. Tormählen NM, et al. J Med Chem. 2022 Jan 27;65(2):1225-1242. doi: 10.1021/acs.jmedchem.0c01773. Epub 2021 May 11. J Med Chem. 2022. PMID: 33974419

10

Pharmacokinetic Optimization of Small Molecule Janus Kinase 3 Inhibitors to Target Immune Cells.

Laux J, Forster M, Riexinger L, Schwamborn A, Guezguez J, Pokoj C, Kudolo M, Berger LM, Knapp S, Schollmeyer D, Guse J, Burnet M, Laufer SA. Laux J, et al. Among authors: laufer sa. ACS Pharmacol Transl Sci. 2022 Jul 14;5(8):573-602. doi: 10.1021/acsptsci.2c00054. eCollection 2022 Aug 12. ACS Pharmacol Transl Sci. 2022. PMID: 35983274 Free PMC article.

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