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Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E2 receptor EP2 subtype.
Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y. Qu C, et al. Among authors: shen dd, shen q. Sci Adv. 2021 Apr 2;7(14):eabf1268. doi: 10.1126/sciadv.abf1268. Print 2021 Apr. Sci Adv. 2021. PMID: 33811074 Free PMC article.
Structure and dynamics of the active human parathyroid hormone receptor-1.
Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y. Zhao LH, et al. Among authors: shen dd. Science. 2019 Apr 12;364(6436):148-153. doi: 10.1126/science.aav7942. Science. 2019. PMID: 30975883 Free PMC article.
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.
Yin W, Mao C, Luan X, Shen DD, Shen Q, Su H, Wang X, Zhou F, Zhao W, Gao M, Chang S, Xie YC, Tian G, Jiang HW, Tao SC, Shen J, Jiang Y, Jiang H, Xu Y, Zhang S, Zhang Y, Xu HE. Yin W, et al. Among authors: shen dd, shen q, shen j. Science. 2020 Jun 26;368(6498):1499-1504. doi: 10.1126/science.abc1560. Epub 2020 May 1. Science. 2020. PMID: 32358203 Free PMC article.
Cryo-EM structures of inactive and active GABAB receptor.
Mao C, Shen C, Li C, Shen DD, Xu C, Zhang S, Zhou R, Shen Q, Chen LN, Jiang Z, Liu J, Zhang Y. Mao C, et al. Among authors: shen dd, shen c, shen q. Cell Res. 2020 Jul;30(7):564-573. doi: 10.1038/s41422-020-0350-5. Epub 2020 Jun 3. Cell Res. 2020. PMID: 32494023 Free PMC article.
Structural basis of GPBAR activation and bile acid recognition.
Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y. Yang F, et al. Among authors: shen y, shen dd, shen q. Nature. 2020 Nov;587(7834):499-504. doi: 10.1038/s41586-020-2569-1. Epub 2020 Jul 22. Nature. 2020. PMID: 32698187
Structural basis for activation of the growth hormone-releasing hormone receptor.
Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW. Zhou F, et al. Among authors: shen dd. Nat Commun. 2020 Oct 15;11(1):5205. doi: 10.1038/s41467-020-18945-0. Nat Commun. 2020. PMID: 33060564 Free PMC article.
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.
Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW. Sun W, et al. Among authors: shen dd. Cell Res. 2020 Dec;30(12):1098-1108. doi: 10.1038/s41422-020-00442-0. Epub 2020 Nov 25. Cell Res. 2020. PMID: 33239759 Free PMC article.
Structures of the glucocorticoid-bound adhesion receptor GPR97-Go complex.
Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP. Ping YQ, et al. Among authors: shen dd, shen q. Nature. 2021 Jan;589(7843):620-626. doi: 10.1038/s41586-020-03083-w. Epub 2021 Jan 6. Nature. 2021. PMID: 33408414
301 results