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FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.
Reilly SM, Abu-Odeh M, Ameka M, DeLuca JH, Naber MC, Dadpey B, Ebadat N, Gomez AV, Peng X, Poirier B, Walk E, Potthoff MJ, Saltiel AR. Reilly SM, et al. Among authors: peng x. J Clin Invest. 2021 May 17;131(10):e145546. doi: 10.1172/JCI145546. J Clin Invest. 2021. PMID: 33822771 Free PMC article.
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.
Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR. Reilly SM, et al. Among authors: peng x. Nat Commun. 2015 Jan 12;6:6047. doi: 10.1038/ncomms7047. Nat Commun. 2015. PMID: 25581158 Free PMC article. Clinical Trial.
Signaling through the nicotinic acetylcholine receptor in the liver protects against the development of metabolic dysfunction-associated steatohepatitis.
Jun H, Liu S, Knights AJ, Zhu K, Ma Y, Gong J, Lenhart AE, Peng X, Huang Y, Ginder JP, Downie CH, Ramos ET, Kullander K, Kennedy RT, Xu XZS, Wu J. Jun H, et al. Among authors: peng x. PLoS Biol. 2024 Jul 19;22(7):e3002728. doi: 10.1371/journal.pbio.3002728. eCollection 2024 Jul. PLoS Biol. 2024. PMID: 39028754 Free PMC article.
HMOX1-LDHB interaction promotes ferroptosis by inducing mitochondrial dysfunction in foamy macrophages during advanced atherosclerosis.
Peng X, Sun B, Tang C, Shi C, Xie X, Wang X, Jiang D, Li S, Jia Y, Wang Y, Tang H, Zhong S, Piao M, Cui X, Zhang S, Wang F, Wang Y, Na R, Huang R, Jiang Y, Zhang W, Xu J, Lin K, Guo J, Pan Z, Wang K, Zhao Q, Liu H, Yu B, Ji Y, Zhang J, Li S, Tian J. Peng X, et al. Dev Cell. 2024 Dec 18:S1534-5807(24)00733-0. doi: 10.1016/j.devcel.2024.12.011. Online ahead of print. Dev Cell. 2024. PMID: 39731912
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