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Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.
Trudler D, Nazor KL, Eisele YS, Grabauskas T, Dolatabadi N, Parker J, Sultan A, Zhong Z, Goodwin MS, Levites Y, Golde TE, Kelly JW, Sierks MR, Schork NJ, Karin M, Ambasudhan R, Lipton SA. Trudler D, et al. Among authors: goodwin ms. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2025847118. doi: 10.1073/pnas.2025847118. Proc Natl Acad Sci U S A. 2021. PMID: 33833060 Free PMC article.
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, Janus C, Chakrabarty P, Judge AR, Brusko TM, de Kloet AD, Krause EG, Golde TE. Futch HS, et al. Among authors: goodwin ms. J Exp Med. 2019 Nov 4;216(11):2479-2491. doi: 10.1084/jem.20190430. Epub 2019 Aug 29. J Exp Med. 2019. PMID: 31467037 Free PMC article.
Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS.
Goodwin MS, Croft CL, Futch HS, Ryu D, Ceballos-Diaz C, Liu X, Paterno G, Mejia C, Deng D, Menezes K, Londono L, Arjona K, Parianos M, Truong V, Rostonics E, Hernandez A, Boye SL, Boye SE, Levites Y, Cruz PE, Golde TE. Goodwin MS, et al. Mol Neurodegener. 2020 Mar 2;15(1):15. doi: 10.1186/s13024-020-00361-z. Mol Neurodegener. 2020. PMID: 32122372 Free PMC article.
Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions.
Croft CL, Goodwin MS, Ryu DH, Lessard CB, Tejeda G, Marrero M, Vause AR, Paterno G, Cruz PE, Lewis J, Giasson BI, Golde TE. Croft CL, et al. Among authors: goodwin ms. Acta Neuropathol. 2021 Mar;141(3):359-381. doi: 10.1007/s00401-021-02264-9. Epub 2021 Jan 26. Acta Neuropathol. 2021. PMID: 33496840 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 35109342
LRP1 is a neuronal receptor for α-synuclein uptake and spread.
Chen K, Martens YA, Meneses A, Ryu DH, Lu W, Raulin AC, Li F, Zhao J, Chen Y, Jin Y, Linares C, Goodwin M, Li Y, Liu CC, Kanekiyo T, Holtzman DM, Golde TE, Bu G, Zhao N. Chen K, et al. Mol Neurodegener. 2022 Sep 2;17(1):57. doi: 10.1186/s13024-022-00560-w. Mol Neurodegener. 2022. PMID: 36056345 Free PMC article.
85 results