Humphrey SJ - Search Results

1

TSC-insensitive Rheb mutations induce oncogenic transformation through a combination of constitutively active mTORC1 signalling and proteome remodelling.

Xie J, De Poi SP, Humphrey SJ, Hein LK, Bruning JB, Pan W, Selth LA, Sargeant TJ, Proud CG. Xie J, et al. Among authors: humphrey sj. Cell Mol Life Sci. 2021 Apr;78(8):4035-4052. doi: 10.1007/s00018-021-03825-7. Epub 2021 Apr 8. Cell Mol Life Sci. 2021. PMID: 33834258 Free PMC article.

2

RagC phosphorylation autoregulates mTOR complex 1.

Yang G, Humphrey SJ, Murashige DS, Francis D, Wang QP, Cooke KC, Neely GG, James DE. Yang G, et al. Among authors: humphrey sj. EMBO J. 2019 Feb 1;38(3):e99548. doi: 10.15252/embj.201899548. Epub 2018 Dec 14. EMBO J. 2019. PMID: 30552228 Free PMC article.

3

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.

Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stöckli J, James DE. Minard AY, et al. Among authors: humphrey sj. Cell Rep. 2016 Sep 27;17(1):29-36. doi: 10.1016/j.celrep.2016.08.086. Cell Rep. 2016. PMID: 27681418 Free PMC article.

4

A TOR (target of rapamycin) and nutritional phosphoproteome of fission yeast reveals novel targets in networks conserved in humans.

Halova L, Cobley D, Franz-Wachtel M, Wang T, Morrison KR, Krug K, Nalpas N, Maček B, Hagan IM, Humphrey SJ, Petersen J. Halova L, et al. Among authors: humphrey sj. Open Biol. 2021 Apr;11(4):200405. doi: 10.1098/rsob.200405. Epub 2021 Apr 7. Open Biol. 2021. PMID: 33823663 Free PMC article.

5

Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.

Wang T, Woodman P, Humphrey SJ, Petersen J. Wang T, et al. Among authors: humphrey sj. Life Sci Alliance. 2022 Feb 4;5(5):e202101082. doi: 10.26508/lsa.202101082. Print 2022 May. Life Sci Alliance. 2022. PMID: 35121625 Free PMC article.

6

Synergistic Targeting of DNA-PK and KIT Signaling Pathways in KIT Mutant Acute Myeloid Leukemia.

Murray HC, Miller K, Brzozowski JS, Kahl RGS, Smith ND, Humphrey SJ, Dun MD, Verrills NM. Murray HC, et al. Among authors: humphrey sj. Mol Cell Proteomics. 2023 Mar;22(3):100503. doi: 10.1016/j.mcpro.2023.100503. Epub 2023 Jan 20. Mol Cell Proteomics. 2023. PMID: 36682716 Free PMC article.

7

The genetic and dietary landscape of the muscle insulin signalling network.

van Gerwen J, Masson SWC, Cutler HB, Vegas AD, Potter M, Stöckli J, Madsen S, Nelson ME, Humphrey SJ, James DE. van Gerwen J, et al. Among authors: humphrey sj. Elife. 2024 Feb 8;12:RP89212. doi: 10.7554/eLife.89212. Elife. 2024. PMID: 38329473 Free PMC article.

8

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.

Yang G, Murashige DS, Humphrey SJ, James DE. Yang G, et al. Among authors: humphrey sj. Cell Rep. 2015 Aug 11;12(6):937-43. doi: 10.1016/j.celrep.2015.07.016. Epub 2015 Jul 30. Cell Rep. 2015. PMID: 26235620 Free article.

9

The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin.

Krycer JR, Fazakerley DJ, Cater RJ, C Thomas K, Naghiloo S, Burchfield JG, Humphrey SJ, Vandenberg RJ, Ryan RM, James DE. Krycer JR, et al. Among authors: humphrey sj. FEBS Lett. 2017 Jan;591(2):322-330. doi: 10.1002/1873-3468.12549. Epub 2017 Jan 13. FEBS Lett. 2017. PMID: 28032905 Free article.

10

Illuminating the dark phosphoproteome.

Needham EJ, Parker BL, Burykin T, James DE, Humphrey SJ. Needham EJ, et al. Among authors: humphrey sj. Sci Signal. 2019 Jan 22;12(565):eaau8645. doi: 10.1126/scisignal.aau8645. Sci Signal. 2019. PMID: 30670635 Review.

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