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Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation.
van der Welle REN, Jobling R, Burns C, Sanza P, van der Beek JA, Fasano A, Chen L, Zwartkruis FJ, Zwakenberg S, Griffin EF, Ten Brink C, Veenendaal T, Liv N, van Ravenswaaij-Arts CMA, Lemmink HH, Pfundt R, Blaser S, Sepulveda C, Lozano AM, Yoon G, Santiago-Sim T, Asensio CS, Caldwell GA, Caldwell KA, Chitayat D, Klumperman J. van der Welle REN, et al. Among authors: klumperman j. EMBO Mol Med. 2021 May 7;13(5):e13258. doi: 10.15252/emmm.202013258. Epub 2021 Apr 14. EMBO Mol Med. 2021. PMID: 33851776 Free PMC article.
Vps33B is required for delivery of endocytosed cargo to lysosomes.
Galmes R, ten Brink C, Oorschot V, Veenendaal T, Jonker C, van der Sluijs P, Klumperman J. Galmes R, et al. Among authors: klumperman j. Traffic. 2015 Dec;16(12):1288-305. doi: 10.1111/tra.12334. Epub 2015 Oct 21. Traffic. 2015. PMID: 26403612 Free article.
HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.
Tol MJ, van der Lienden MJC, Gabriel TL, Hagen JJ, Scheij S, Veenendaal T, Klumperman J, Donker-Koopman WE, Verhoeven AJ, Overkleeft H, Aerts JM, Argmann CA, van Eijk M. Tol MJ, et al. Among authors: klumperman j. Autophagy. 2018;14(3):437-449. doi: 10.1080/15548627.2017.1419118. Epub 2018 Feb 17. Autophagy. 2018. PMID: 29455584 Free PMC article.
197 results