Ohrui H - Search Results

1

Intriguing Antiviral Modified Nucleosides: A Retrospective View into the Future Treatment of COVID-19.

Ami EI, Ohrui H. Ami EI, et al. Among authors: ohrui h. ACS Med Chem Lett. 2021 Mar 29;12(4):510-517. doi: 10.1021/acsmedchemlett.1c00070. eCollection 2021 Apr 8. ACS Med Chem Lett. 2021. PMID: 33854700 Free PMC article.

2

Chiral synthesis of the BC-ring system of ciguatoxin from D-glucose.

Ami E, Kishimoto H, Ohrui H, Meguro H. Ami E, et al. Among authors: ohrui h. Biosci Biotechnol Biochem. 1997 Dec;61(12):2019-24. doi: 10.1271/bbb.61.2019. Biosci Biotechnol Biochem. 1997. PMID: 9438983 Free article. No abstract available.

3

Study on the Application of the (S)-2-tert-Butyl-2-methyl-1,3-benzodioxole-4-carboxylic acid-based On-line HPLC-Exciton CD Analysis to Acyclic 1,3-Diols.

Sato S, Shimizu K, Kim JH, Ami E, Akasaka K, Ohrui H. Sato S, et al. Among authors: ohrui h. Biosci Biotechnol Biochem. 1998;62(9):1822-5. doi: 10.1271/bbb.62.1822. Biosci Biotechnol Biochem. 1998. PMID: 27392692 Free article.

4

Lipase-catalyzed Kinetic Resolution of (±)-trans- and cis-2-Azidocycloalkanols.

Ami E, Ohrui H. Ami E, et al. Among authors: ohrui h. Biosci Biotechnol Biochem. 1999;63(12):2150-6. doi: 10.1271/bbb.63.2150. Biosci Biotechnol Biochem. 1999. PMID: 27373917 Free article.

5

A proposed structure of modified nucleosides expected to have high antiviral activity and low toxicity.

Ohrui H. Ohrui H. Nucleosides Nucleotides Nucleic Acids. 2009 Aug;28(8):772-5. doi: 10.1080/15257770903155675. Nucleosides Nucleotides Nucleic Acids. 2009. PMID: 20183616

6

Development of modified nucleosides that have supremely high anti-HIV activity and low toxicity and prevent the emergence of resistant HIV mutants.

Ohrui H. Ohrui H. Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(3):53-65. doi: 10.2183/pjab.87.53. Proc Jpn Acad Ser B Phys Biol Sci. 2011. PMID: 21422739 Free PMC article.

7

2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma.

Ohrui H, Kohgo S, Hayakawa H, Kodama E, Matsuoka M, Nakata T, Mitsuya H. Ohrui H, et al. Nucleic Acids Symp Ser (Oxf). 2006;(50):1-2. doi: 10.1093/nass/nrl001. Nucleic Acids Symp Ser (Oxf). 2006. PMID: 17150787

8

Syntheses of 4'-C-ethynyl-beta-D-arabino- and 4'-C-ethynyl-2'-deoxy-beta-D-ribo-pentofuranosylpyrimidines and -purines and evaluation of their anti-HIV activity.

Ohrui H, Kohgo S, Kitano K, Sakata S, Kodama E, Yoshimura K, Matsuoka M, Shigeta S, Mitsuya H. Ohrui H, et al. J Med Chem. 2000 Nov 16;43(23):4516-25. doi: 10.1021/jm000209n. J Med Chem. 2000. PMID: 11087576

9

Synthesis of nucleotide analogues, EFdA, EdA and EdAP, and the effect of EdAP on hepatitis B virus replication.

Kamata M, Takeuchi T, Hayashi E, Nishioka K, Oshima M, Iwamoto M, Nishiuchi K, Kamo S, Tomoshige S, Watashi K, Kamisuki S, Ohrui H, Sugawara F, Kuramochi K. Kamata M, et al. Among authors: ohrui h. Biosci Biotechnol Biochem. 2020 Feb;84(2):217-227. doi: 10.1080/09168451.2019.1673696. Epub 2019 Oct 7. Biosci Biotechnol Biochem. 2020. PMID: 31589093

10

Synthesis of novel 4'-C-methyl-pyrimidine nucleosides and their biological activities.

Kitano K, Machida H, Miura S, Ohrui H. Kitano K, et al. Among authors: ohrui h. Bioorg Med Chem Lett. 1999 Mar 22;9(6):827-30. doi: 10.1016/s0960-894x(99)00090-6. Bioorg Med Chem Lett. 1999. PMID: 10206544

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