Arnold E - Search Results

1

Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer.

Tuske S, Zheng J, Olson ED, Ruiz FX, Pascal BD, Hoang A, Bauman JD, Das K, DeStefano JJ, Musier-Forsyth K, Griffin PR, Arnold E. Tuske S, et al. Among authors: arnold e. Curr Res Struct Biol. 2020;2:116-129. doi: 10.1016/j.crstbi.2020.06.002. Epub 2020 Jun 30. Curr Res Struct Biol. 2020. PMID: 33870216 Free PMC article.

2

Structural basis of BLyS receptor recognition.

Oren DA, Li Y, Volovik Y, Morris TS, Dharia C, Das K, Galperina O, Gentz R, Arnold E. Oren DA, et al. Among authors: arnold e. Nat Struct Biol. 2002 Apr;9(4):288-92. doi: 10.1038/nsb769. Nat Struct Biol. 2002. PMID: 11862220

3

Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

Sarafianos SG, Clark AD Jr, Das K, Tuske S, Birktoft JJ, Ilankumaran P, Ramesha AR, Sayer JM, Jerina DM, Boyer PL, Hughes SH, Arnold E. Sarafianos SG, et al. Among authors: arnold e. EMBO J. 2002 Dec 2;21(23):6614-24. doi: 10.1093/emboj/cdf637. EMBO J. 2002. PMID: 12456667 Free PMC article.

4

Trapping HIV-1 reverse transcriptase before and after translocation on DNA.

Sarafianos SG, Clark AD Jr, Tuske S, Squire CJ, Das K, Sheng D, Ilankumaran P, Ramesha AR, Kroth H, Sayer JM, Jerina DM, Boyer PL, Hughes SH, Arnold E. Sarafianos SG, et al. Among authors: arnold e. J Biol Chem. 2003 May 2;278(18):16280-8. doi: 10.1074/jbc.M212911200. Epub 2003 Jan 28. J Biol Chem. 2003. PMID: 12554739 Free article.

5

Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site.

Das K, Acton T, Chiang Y, Shih L, Arnold E, Montelione GT. Das K, et al. Among authors: arnold e. Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4041-6. doi: 10.1073/pnas.0400189101. Epub 2004 Mar 3. Proc Natl Acad Sci U S A. 2004. PMID: 14999102 Free PMC article.

6

Crystal structures of arginine deiminase with covalent reaction intermediates; implications for catalytic mechanism.

Das K, Butler GH, Kwiatkowski V, Clark AD Jr, Yadav P, Arnold E. Das K, et al. Among authors: arnold e. Structure. 2004 Apr;12(4):657-67. doi: 10.1016/j.str.2004.02.017. Structure. 2004. PMID: 15062088 Free article.

7

Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.

Tuske S, Sarafianos SG, Clark AD Jr, Ding J, Naeger LK, White KL, Miller MD, Gibbs CS, Boyer PL, Clark P, Wang G, Gaffney BL, Jones RA, Jerina DM, Hughes SH, Arnold E. Tuske S, et al. Among authors: arnold e. Nat Struct Mol Biol. 2004 May;11(5):469-74. doi: 10.1038/nsmb760. Epub 2004 Apr 25. Nat Struct Mol Biol. 2004. PMID: 15107837

8

Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.

Das K, Clark AD Jr, Lewi PJ, Heeres J, De Jonge MR, Koymans LM, Vinkers HM, Daeyaert F, Ludovici DW, Kukla MJ, De Corte B, Kavash RW, Ho CY, Ye H, Lichtenstein MA, Andries K, Pauwels R, De Béthune MP, Boyer PL, Clark P, Hughes SH, Janssen PA, Arnold E. Das K, et al. Among authors: arnold e. J Med Chem. 2004 May 6;47(10):2550-60. doi: 10.1021/jm030558s. J Med Chem. 2004. PMID: 15115397

9

Crystallography and the design of anti-AIDS drugs: conformational flexibility and positional adaptability are important in the design of non-nucleoside HIV-1 reverse transcriptase inhibitors.

Das K, Lewi PJ, Hughes SH, Arnold E. Das K, et al. Among authors: arnold e. Prog Biophys Mol Biol. 2005 Jun;88(2):209-31. doi: 10.1016/j.pbiomolbio.2004.07.001. Prog Biophys Mol Biol. 2005. PMID: 15572156 Free article. Review.

10

Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases.

Sarafianos SG, Das K, Hughes SH, Arnold E. Sarafianos SG, et al. Among authors: arnold e. Curr Opin Struct Biol. 2004 Dec;14(6):716-30. doi: 10.1016/j.sbi.2004.10.013. Curr Opin Struct Biol. 2004. PMID: 15582396 Review.

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