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Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.
Ma C, Sacco MD, Hurst B, Townsend JA, Hu Y, Szeto T, Zhang X, Tarbet B, Marty MT, Chen Y, Wang J. Ma C, et al. Among authors: szeto t. bioRxiv [Preprint]. 2020 Jan 6:2020.04.20.051581. doi: 10.1101/2020.04.20.051581. bioRxiv. 2020. Update in: Cell Res. 2020 Aug;30(8):678-692. doi: 10.1038/s41422-020-0356-z PMID: 32511378 Free PMC article. Updated. Preprint.
Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay.
Ma C, Sacco MD, Xia Z, Lambrinidis G, Townsend JA, Hu Y, Meng X, Szeto T, Ba M, Zhang X, Gongora M, Zhang F, Marty MT, Xiang Y, Kolocouris A, Chen Y, Wang J. Ma C, et al. Among authors: szeto t. ACS Cent Sci. 2021 Jul 28;7(7):1245-1260. doi: 10.1021/acscentsci.1c00519. Epub 2021 Jun 18. ACS Cent Sci. 2021. PMID: 34341772 Free PMC article.
Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir.
Xia Z, Sacco M, Hu Y, Ma C, Meng X, Zhang F, Szeto T, Xiang Y, Chen Y, Wang J. Xia Z, et al. Among authors: szeto t. ACS Pharmacol Transl Sci. 2021 Jun 9;4(4):1408-1421. doi: 10.1021/acsptsci.1c00099. eCollection 2021 Aug 13. ACS Pharmacol Transl Sci. 2021. PMID: 34414360 Free PMC article.
Discovery of SARS-CoV-2 papain-like protease inhibitors through a combination of high-throughput screening and FlipGFP-based reporter assay.
Xia Z, Sacco MD, Ma C, Townsend JA, Kitamura N, Hu Y, Ba M, Szeto T, Zhang X, Meng X, Zhang F, Xiang Y, Marty MT, Chen Y, Wang J. Xia Z, et al. Among authors: szeto t. bioRxiv [Preprint]. 2021 Mar 16:2021.03.15.435551. doi: 10.1101/2021.03.15.435551. bioRxiv. 2021. Update in: ACS Cent Sci. 2021 Jul 28;7(7):1245-1260. doi: 10.1021/acscentsci.1c00519 PMID: 33758866 Free PMC article. Updated. Preprint.
Molecular Pharming for low and middle income countries.
Murad S, Fuller S, Menary J, Moore C, Pinneh E, Szeto T, Hitzeroth I, Freire M, Taychakhoonavudh S, Phoolcharoen W, Ma JK. Murad S, et al. Among authors: szeto t. Curr Opin Biotechnol. 2020 Feb;61:53-59. doi: 10.1016/j.copbio.2019.10.005. Epub 2019 Nov 18. Curr Opin Biotechnol. 2020. PMID: 31751895 Review.
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