Lauffenburger DA - Search Results

1

Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease.

Madrasi K, Das R, Mohmmadabdul H, Lin L, Hyman BT, Lauffenburger DA, Albers MW, Rissman RA, Burke JM, Apgar JF, Wille L, Gruenbaum L, Hua F. Madrasi K, et al. Among authors: lauffenburger da. Alzheimers Dement. 2021 Sep;17(9):1487-1498. doi: 10.1002/alz.12312. Epub 2021 May 2. Alzheimers Dement. 2021. PMID: 33938131 Free PMC article.

2

Effects of Bcl-2 levels on Fas signaling-induced caspase-3 activation: molecular genetic tests of computational model predictions.

Hua F, Cornejo MG, Cardone MH, Stokes CL, Lauffenburger DA. Hua F, et al. Among authors: lauffenburger da. J Immunol. 2005 Jul 15;175(2):985-95. doi: 10.4049/jimmunol.175.2.985. J Immunol. 2005. PMID: 16002698

3

Integrated mechanistic and data-driven modelling for multivariate analysis of signalling pathways.

Hua F, Hautaniemi S, Yokoo R, Lauffenburger DA. Hua F, et al. Among authors: lauffenburger da. J R Soc Interface. 2006 Aug 22;3(9):515-26. doi: 10.1098/rsif.2005.0109. J R Soc Interface. 2006. PMID: 16849248 Free PMC article.

4

Physicochemical modelling of cell signalling pathways.

Aldridge BB, Burke JM, Lauffenburger DA, Sorger PK. Aldridge BB, et al. Among authors: lauffenburger da. Nat Cell Biol. 2006 Nov;8(11):1195-203. doi: 10.1038/ncb1497. Nat Cell Biol. 2006. PMID: 17060902 Review.

5

Quantitative network signal combinations downstream of TCR activation can predict IL-2 production response.

Kemp ML, Wille L, Lewis CL, Nicholson LB, Lauffenburger DA. Kemp ML, et al. Among authors: lauffenburger da. J Immunol. 2007 Apr 15;178(8):4984-92. doi: 10.4049/jimmunol.178.8.4984. J Immunol. 2007. PMID: 17404280

6

Epi-allelic Erk1 and Erk2 knockdown series for quantitative analysis of T cell Erk regulation and IL-2 production.

Wille L, Kemp ML, Sandy P, Lewis CL, Lauffenburger DA. Wille L, et al. Among authors: lauffenburger da. Mol Immunol. 2007 May;44(12):3085-91. doi: 10.1016/j.molimm.2007.02.008. Epub 2007 Apr 5. Mol Immunol. 2007. PMID: 17418417 Free PMC article.

7

Modeling a snap-action, variable-delay switch controlling extrinsic cell death.

Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Albeck JG, et al. Among authors: lauffenburger da. PLoS Biol. 2008 Dec 2;6(12):2831-52. doi: 10.1371/journal.pbio.0060299. PLoS Biol. 2008. PMID: 19053173 Free PMC article.

8

Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks.

Kirouac DC, Saez-Rodriguez J, Swantek J, Burke JM, Lauffenburger DA, Sorger PK. Kirouac DC, et al. Among authors: lauffenburger da. BMC Syst Biol. 2012 May 1;6:29. doi: 10.1186/1752-0509-6-29. BMC Syst Biol. 2012. PMID: 22548703 Free PMC article.

9

Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening.

Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Wood LB, et al. Among authors: lauffenburger da. Sci Rep. 2015 Nov 13;5:16622. doi: 10.1038/srep16622. Sci Rep. 2015. PMID: 26564777 Free PMC article.

10

Profiling drugs for rheumatoid arthritis that inhibit synovial fibroblast activation.

Jones DS, Jenney AP, Swantek JL, Burke JM, Lauffenburger DA, Sorger PK. Jones DS, et al. Among authors: lauffenburger da. Nat Chem Biol. 2017 Jan;13(1):38-45. doi: 10.1038/nchembio.2211. Epub 2016 Oct 31. Nat Chem Biol. 2017. PMID: 27820799 Free PMC article.

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