Yuan T - Search Results

1

Programmable RNA editing with compact CRISPR-Cas13 systems from uncultivated microbes.

Xu C, Zhou Y, Xiao Q, He B, Geng G, Wang Z, Cao B, Dong X, Bai W, Wang Y, Wang X, Zhou D, Yuan T, Huo X, Lai J, Yang H. Xu C, et al. Among authors: yuan t. Nat Methods. 2021 May;18(5):499-506. doi: 10.1038/s41592-021-01124-4. Epub 2021 May 3. Nat Methods. 2021. PMID: 33941935

2

Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.

Zuo E, Sun Y, Wei W, Yuan T, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H. Zuo E, et al. Among authors: yuan t, yuan l. Science. 2019 Apr 19;364(6437):289-292. doi: 10.1126/science.aav9973. Epub 2019 Feb 28. Science. 2019. PMID: 30819928 Free PMC article.

3

A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects.

Zuo E, Sun Y, Yuan T, He B, Zhou C, Ying W, Liu J, Wei W, Zeng R, Li Y, Yang H. Zuo E, et al. Among authors: yuan t. Nat Methods. 2020 Jun;17(6):600-604. doi: 10.1038/s41592-020-0832-x. Epub 2020 May 18. Nat Methods. 2020. PMID: 32424272

4

GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos.

Zuo E, Sun Y, Wei W, Yuan T, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H. Zuo E, et al. Among authors: yuan t, yuan l. Nat Protoc. 2020 Sep;15(9):3009-3029. doi: 10.1038/s41596-020-0361-1. Epub 2020 Aug 14. Nat Protoc. 2020. PMID: 32796939 Free PMC article.

5

Optimization of C-to-G base editors with sequence context preference predictable by machine learning methods.

Yuan T, Yan N, Fei T, Zheng J, Meng J, Li N, Liu J, Zhang H, Xie L, Ying W, Li D, Shi L, Sun Y, Li Y, Li Y, Sun Y, Zuo E. Yuan T, et al. Nat Commun. 2021 Aug 12;12(1):4902. doi: 10.1038/s41467-021-25217-y. Nat Commun. 2021. PMID: 34385461 Free PMC article.

6

Author Correction: Programmable RNA editing with compact CRISPR-Cas13 systems from uncultivated microbes.

Xu C, Zhou Y, Xiao Q, He B, Geng G, Wang Z, Cao B, Dong X, Bai W, Wang Y, Wang X, Zhou D, Yuan T, Huo X, Lai J, Yang H. Xu C, et al. Among authors: yuan t. Nat Methods. 2022 Feb;19(2):255. doi: 10.1038/s41592-021-01379-x. Nat Methods. 2022. PMID: 34975157 No abstract available.

7

Cytosine base editors induce off-target mutations and adverse phenotypic effects in transgenic mice.

Yan N, Feng H, Sun Y, Xin Y, Zhang H, Lu H, Zheng J, He C, Zuo Z, Yuan T, Li N, Xie L, Wei W, Sun Y, Zuo E. Yan N, et al. Among authors: yuan t. Nat Commun. 2023 Mar 30;14(1):1784. doi: 10.1038/s41467-023-37508-7. Nat Commun. 2023. PMID: 36997536 Free PMC article.

8

Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation.

Li G, Dong X, Luo J, Yuan T, Li T, Zhao G, Zhang H, Zhou J, Zeng Z, Cui S, Wang H, Wang Y, Yu Y, Yuan Y, Zuo E, Xu C, Huang J, Zhou Y. Li G, et al. Among authors: yuan t, yuan y. Nat Commun. 2024 Sep 16;15(1):8090. doi: 10.1038/s41467-024-52485-1. Nat Commun. 2024. PMID: 39284833 Free PMC article.

9

Author Correction: Engineering TadA ortholog-derived cytosine base editor without motif preference and adenosine activity limitation.

Li G, Dong X, Luo J, Yuan T, Li T, Zhao G, Zhang H, Zhou J, Zeng Z, Cui S, Wang H, Wang Y, Yu Y, Yuan Y, Zuo E, Xu C, Huang J, Zhou Y. Li G, et al. Among authors: yuan t, yuan y. Nat Commun. 2024 Oct 18;15(1):9001. doi: 10.1038/s41467-024-53171-y. Nat Commun. 2024. PMID: 39424826 Free PMC article. No abstract available.

10

Adenine base editors induce off-target structure variations in mouse embryos and primary human T cells.

Wu L, Jiang S, Shi M, Yuan T, Li Y, Huang P, Li Y, Zuo E, Zhou C, Sun Y. Wu L, et al. Among authors: yuan t. Genome Biol. 2024 Nov 11;25(1):291. doi: 10.1186/s13059-024-03434-0. Genome Biol. 2024. PMID: 39529170 Free PMC article.

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