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SARS-COV-2 induced Diarrhea is inflammatory, Ca 2+ Dependent and involves activation of calcium activated Cl channels.
Donowitz M, Tse CM, Dokladny K, Rawat M, Horwitz I, Ye C, Kell A, Lin R, Lee S, Guo C, Tsai SJ, Cox A, Gould S, In J, Bradfute S, Zachos NC, Kovbasnjuk O. Donowitz M, et al. Among authors: kovbasnjuk o. bioRxiv [Preprint]. 2021 Apr 28:2021.04.27.441695. doi: 10.1101/2021.04.27.441695. bioRxiv. 2021. PMID: 33948596 Free PMC article. Preprint.
Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process.
Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M. Zizak M, et al. Among authors: kovbasnjuk o. J Biol Chem. 2012 Apr 13;287(16):13442-56. doi: 10.1074/jbc.M111.307256. Epub 2012 Feb 27. J Biol Chem. 2012. PMID: 22371496 Free PMC article.
NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells.
Yang J, Singh V, Cha B, Chen TE, Sarker R, Murtazina R, Jin S, Zachos NC, Patterson GH, Tse CM, Kovbasnjuk O, Li X, Donowitz M. Yang J, et al. Among authors: kovbasnjuk o. J Biol Chem. 2013 Jun 7;288(23):16960-16974. doi: 10.1074/jbc.M113.470799. Epub 2013 Apr 23. J Biol Chem. 2013. PMID: 23612977 Free PMC article.
78 results