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Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses.
Saunders KO, Lee E, Parks R, Martinez DR, Li D, Chen H, Edwards RJ, Gobeil S, Barr M, Mansouri K, Alam SM, Sutherland LL, Cai F, Sanzone AM, Berry M, Manne K, Bock KW, Minai M, Nagata BM, Kapingidza AB, Azoitei M, Tse LV, Scobey TD, Spreng RL, Rountree RW, DeMarco CT, Denny TN, Woods CW, Petzold EW, Tang J, Oguin TH 3rd, Sempowski GD, Gagne M, Douek DC, Tomai MA, Fox CB, Seder R, Wiehe K, Weissman D, Pardi N, Golding H, Khurana S, Acharya P, Andersen H, Lewis MG, Moore IN, Montefiori DC, Baric RS, Haynes BF. Saunders KO, et al. Among authors: gobeil s. Nature. 2021 Jun;594(7864):553-559. doi: 10.1038/s41586-021-03594-0. Epub 2021 May 10. Nature. 2021. PMID: 33971664 Free PMC article.
Controlling the SARS-CoV-2 Spike Glycoprotein Conformation.
Henderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil S, Kopp M, Hsu A, Borgnia M, Parks R, Haynes BF, Acharya P. Henderson R, et al. Among authors: gobeil s. bioRxiv [Preprint]. 2020 May 18:2020.05.18.102087. doi: 10.1101/2020.05.18.102087. bioRxiv. 2020. Update in: Nat Struct Mol Biol. 2020 Oct;27(10):925-933. doi: 10.1038/s41594-020-0479-4 PMID: 32511343 Free PMC article. Updated. Preprint.
Controlling the SARS-CoV-2 spike glycoprotein conformation.
Henderson R, Edwards RJ, Mansouri K, Janowska K, Stalls V, Gobeil SMC, Kopp M, Li D, Parks R, Hsu AL, Borgnia MJ, Haynes BF, Acharya P. Henderson R, et al. Nat Struct Mol Biol. 2020 Oct;27(10):925-933. doi: 10.1038/s41594-020-0479-4. Epub 2020 Jul 22. Nat Struct Mol Biol. 2020. PMID: 32699321 Free PMC article.
Cold sensitivity of the SARS-CoV-2 spike ectodomain.
Edwards RJ, Mansouri K, Stalls V, Manne K, Watts B, Parks R, Janowska K, Gobeil SMC, Kopp M, Li D, Lu X, Mu Z, Deyton M, Oguin TH, Sprenz J, Williams W, Saunders K, Montefiori D, Sempowski GD, Henderson R, Alam M, Haynes BF, Acharya P. Edwards RJ, et al. bioRxiv [Preprint]. 2020 Oct 13:2020.07.12.199588. doi: 10.1101/2020.07.12.199588. bioRxiv. 2020. Update in: Nat Struct Mol Biol. 2021 Feb;28(2):128-131. doi: 10.1038/s41594-020-00547-5 PMID: 32699852 Free PMC article. Updated. Preprint.
D614G mutation alters SARS-CoV-2 spike conformational dynamics and protease cleavage susceptibility at the S1/S2 junction.
Gobeil S, Janowska K, McDowell S, Mansouri K, Parks R, Manne K, Stalls V, Kopp M, Henderson R, Edwards RJ, Haynes BF, Acharya P. Gobeil S, et al. bioRxiv [Preprint]. 2020 Oct 12:2020.10.11.335299. doi: 10.1101/2020.10.11.335299. bioRxiv. 2020. Update in: Cell Rep. 2021 Jan 12;34(2):108630. doi: 10.1016/j.celrep.2020.108630 PMID: 33052347 Free PMC article. Updated. Preprint.
D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization.
Weissman D, Alameh MG, de Silva T, Collini P, Hornsby H, Brown R, LaBranche CC, Edwards RJ, Sutherland L, Santra S, Mansouri K, Gobeil S, McDanal C, Pardi N, Hengartner N, Lin PJC, Tam Y, Shaw PA, Lewis MG, Boesler C, Şahin U, Acharya P, Haynes BF, Korber B, Montefiori DC. Weissman D, et al. Among authors: gobeil s. Cell Host Microbe. 2021 Jan 13;29(1):23-31.e4. doi: 10.1016/j.chom.2020.11.012. Epub 2020 Dec 1. Cell Host Microbe. 2021. PMID: 33306985 Free PMC article. Clinical Trial.
Cold sensitivity of the SARS-CoV-2 spike ectodomain.
Edwards RJ, Mansouri K, Stalls V, Manne K, Watts B, Parks R, Janowska K, Gobeil SMC, Kopp M, Li D, Lu X, Mu Z, Deyton M, Oguin TH 3rd, Sprenz J, Williams W, Saunders KO, Montefiori D, Sempowski GD, Henderson R, Munir Alam S, Haynes BF, Acharya P. Edwards RJ, et al. Among authors: gobeil smc. Nat Struct Mol Biol. 2021 Feb;28(2):128-131. doi: 10.1038/s41594-020-00547-5. Epub 2021 Jan 5. Nat Struct Mol Biol. 2021. PMID: 33402708 Free PMC article.
The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates.
Li D, Edwards RJ, Manne K, Martinez DR, Schäfer A, Alam SM, Wiehe K, Lu X, Parks R, Sutherland LL, Oguin TH, McDanal C, Perez LG, Mansouri K, Gobeil SMC, Janowska K, Stalls V, Kopp M, Cai F, Lee E, Foulger A, Hernandez GE, Sanzone A, Tilahun K, Jiang C, Tse LV, Bock KW, Minai M, Nagata BM, Cronin K, Gee-Lai V, Deyton M, Barr M, Holle TV, Macintyre AN, Stover E, Feldman J, Hauser BM, Caradonna TM, Scobey TD, Rountree W, Wang Y, Moody MA, Cain DW, DeMarco CT, Denny T, Woods CW, Petzold EW, Schmidt AG, Teng IT, Zhou T, Kwong PD, Mascola JR, Graham BS, Moore IN, Seder R, Andersen H, Lewis MG, Montefiori DC, Sempowski GD, Baric RS, Acharya P, Haynes BF, Saunders KO. Li D, et al. Among authors: gobeil smc. bioRxiv [Preprint]. 2021 Feb 18:2020.12.31.424729. doi: 10.1101/2020.12.31.424729. bioRxiv. 2021. PMID: 33442694 Free PMC article. Preprint.
SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys.
Saunders KO, Lee E, Parks R, Martinez DR, Li D, Chen H, Edwards RJ, Gobeil S, Barr M, Mansouri K, Alam SM, Sutherland LL, Cai F, Sanzone AM, Berry M, Manne K, Kapingidza AB, Azoitei M, Tse LV, Scobey TD, Spreng RL, Rountree RW, DeMarco CT, Denny TN, Woods CW, Petzold EW, Oguin TH, Sempowski GD, Gagne M, Douek DC, Tomai MA, Fox CB, Seder R, Wiehe K, Weissman D, Pardi N, Acharya P, Andersen H, Lewis MG, Moore IN, Montefiori DC, Baric RS, Haynes BF. Saunders KO, et al. Among authors: gobeil s. bioRxiv [Preprint]. 2021 Feb 17:2021.02.17.431492. doi: 10.1101/2021.02.17.431492. bioRxiv. 2021. PMID: 33619494 Free PMC article. Preprint.
71 results