Albrecht W - Search Results

1

Design and Synthesis of Highly Selective Brain Penetrant p38α Mitogen-Activated Protein Kinase Inhibitors.

Tormählen NM, Martorelli M, Kuhn A, Maier F, Guezguez J, Burnet M, Albrecht W, Laufer SA, Koch P. Tormählen NM, et al. Among authors: albrecht w. J Med Chem. 2022 Jan 27;65(2):1225-1242. doi: 10.1021/acs.jmedchem.0c01773. Epub 2021 May 11. J Med Chem. 2022. PMID: 33974419

2

Synthesis and biological testing of purine derivatives as potential ATP-competitive kinase inhibitors.

Laufer SA, Domeyer DM, Scior TR, Albrecht W, Hauser DR. Laufer SA, et al. Among authors: albrecht w. J Med Chem. 2005 Feb 10;48(3):710-22. doi: 10.1021/jm0408767. J Med Chem. 2005. PMID: 15689155

3

Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-type p38 mitogen-activated protein kinase inhibitor.

Kammerer B, Scheible H, Albrecht W, Gleiter CH, Laufer S. Kammerer B, et al. Among authors: albrecht w. Drug Metab Dispos. 2007 Jun;35(6):875-83. doi: 10.1124/dmd.106.013409. Epub 2007 Mar 7. Drug Metab Dispos. 2007. PMID: 17344341

4

IL-1beta regulates FHL2 and other cytoskeleton-related genes in human chondrocytes.

Joos H, Albrecht W, Laufer S, Reichel H, Brenner RE. Joos H, et al. Among authors: albrecht w. Mol Med. 2008 Mar-Apr;14(3-4):150-9. doi: 10.2119/2007-00118.Joos. Mol Med. 2008. PMID: 18224250 Free PMC article.

5

In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase.

Albrecht W, Unger A, Nussler AK, Laufer S. Albrecht W, et al. Drug Metab Dispos. 2008 May;36(5):894-903. doi: 10.1124/dmd.108.020347. Epub 2008 Feb 11. Drug Metab Dispos. 2008. PMID: 18268076

6

Licofelone suppresses prostaglandin E2 formation by interference with the inducible microsomal prostaglandin E2 synthase-1.

Koeberle A, Siemoneit U, Bühring U, Northoff H, Laufer S, Albrecht W, Werz O. Koeberle A, et al. Among authors: albrecht w. J Pharmacol Exp Ther. 2008 Sep;326(3):975-82. doi: 10.1124/jpet.108.139444. Epub 2008 Jun 11. J Pharmacol Exp Ther. 2008. PMID: 18550688

7

Influence of p38MAPK inhibition on IL-1beta-stimulated human chondrocytes: a microarray approach.

Joos H, Albrecht W, Laufer S, Brenner RE. Joos H, et al. Among authors: albrecht w. Int J Mol Med. 2009 May;23(5):685-93. doi: 10.3892/ijmm_00000181. Int J Mol Med. 2009. PMID: 19360329

8

2-Acylaminopyridin-4-ylimidazoles as p38 MAP kinase inhibitors: Design, synthesis, and biological and metabolic evaluations.

Ziegler K, Hauser DR, Unger A, Albrecht W, Laufer SA. Ziegler K, et al. Among authors: albrecht w. ChemMedChem. 2009 Nov;4(11):1939-48. doi: 10.1002/cmdc.200900242. ChemMedChem. 2009. PMID: 19731280

9

Synthesis and biological testing of N-aminoimidazole-based p38alpha MAP kinase inhibitors.

Bracht C, Hauser DR, Schattel V, Albrecht W, Laufer SA. Bracht C, et al. Among authors: albrecht w. ChemMedChem. 2010 Jul 5;5(7):1134-42. doi: 10.1002/cmdc.201000114. ChemMedChem. 2010. PMID: 20473979

10

Tri- and tetrasubstituted imidazoles as p38α mitogen-activated protein kinase inhibitors.

Laufer S, Hauser D, Stegmiller T, Bracht C, Ruff K, Schattel V, Albrecht W, Koch P. Laufer S, et al. Among authors: albrecht w. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6671-5. doi: 10.1016/j.bmcl.2010.09.012. Epub 2010 Sep 9. Bioorg Med Chem Lett. 2010. PMID: 20934337

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