Koch P - Search Results

1

Design and Synthesis of Highly Selective Brain Penetrant p38α Mitogen-Activated Protein Kinase Inhibitors.

Tormählen NM, Martorelli M, Kuhn A, Maier F, Guezguez J, Burnet M, Albrecht W, Laufer SA, Koch P. Tormählen NM, et al. Among authors: koch p. J Med Chem. 2022 Jan 27;65(2):1225-1242. doi: 10.1021/acs.jmedchem.0c01773. Epub 2021 May 11. J Med Chem. 2022. PMID: 33974419

2

Towards the improvement of the synthesis of novel 4(5)-aryl-5(4)-heteroaryl-2-thio-substituted imidazoles and their p38 MAP kinase inhibitory activity.

Laufer S, Koch P. Laufer S, et al. Among authors: koch p. Org Biomol Chem. 2008 Feb 7;6(3):437-9. doi: 10.1039/b717605h. Epub 2007 Dec 21. Org Biomol Chem. 2008. PMID: 18219408

3

Role of the hydrogen bonding heteroatom-Lys53 interaction between the p38alpha mitogen-activated protein (MAP) kinase and pyridinyl-substituted 5-membered heterocyclic ring inhibitors.

Abu Thaher B, Koch P, Schattel V, Laufer S. Abu Thaher B, et al. Among authors: koch p. J Med Chem. 2009 Apr 23;52(8):2613-7. doi: 10.1021/jm801467h. J Med Chem. 2009. PMID: 19301816

4

Pyridinylquinoxalines and pyridinylpyridopyrazines as lead compounds for novel p38 alpha mitogen-activated protein kinase inhibitors.

Koch P, Jahns H, Schattel V, Goettert M, Laufer S. Koch P, et al. J Med Chem. 2010 Feb 11;53(3):1128-37. doi: 10.1021/jm901392x. J Med Chem. 2010. PMID: 20078117

5

Unexpected reaction of 2-alkylsulfanylimidazoles to imidazol-2-ones: pyridinylimidazol-2-ones as novel potent p38alpha mitogen-activated protein kinase inhibitors.

Koch P, Laufer S. Koch P, et al. J Med Chem. 2010 Jun 24;53(12):4798-802. doi: 10.1021/jm100161q. J Med Chem. 2010. PMID: 20481631

6

Tri- and tetrasubstituted imidazoles as p38α mitogen-activated protein kinase inhibitors.

Laufer S, Hauser D, Stegmiller T, Bracht C, Ruff K, Schattel V, Albrecht W, Koch P. Laufer S, et al. Among authors: koch p. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6671-5. doi: 10.1016/j.bmcl.2010.09.012. Epub 2010 Sep 9. Bioorg Med Chem Lett. 2010. PMID: 20934337

7

Biological evaluation and structural determinants of p38α mitogen-activated-protein kinase and c-Jun-N-terminal kinase 3 inhibition by flavonoids.

Goettert M, Schattel V, Koch P, Merfort I, Laufer S. Goettert M, et al. Among authors: koch p. Chembiochem. 2010 Dec 10;11(18):2579-88. doi: 10.1002/cbic.201000487. Chembiochem. 2010. PMID: 21108268

8

Methyl 4-[5-(4-fluoro-phen-yl)-4-(pyridin-4-yl)-1H-imidazol-2-ylsulfan-yl]butanoate.

Koch P, Bäuerlein C, Schollmeyer D, Laufer S. Koch P, et al. Acta Crystallogr Sect E Struct Rep Online. 2008 Jun 7;64(Pt 7):o1183-4. doi: 10.1107/S1600536808016000. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21202826 Free PMC article.

9

3-(4-Fluoro-phen-yl)-2-(4-pyrid-yl)pyrido[2,3-b]pyrazine.

Koch P, Schollmeyer D, Laufer S. Koch P, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Sep 26;65(Pt 10):o2546. doi: 10.1107/S1600536809037970. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21577988 Free PMC article.

10

5-(4-Fluoro-phen-yl)-4-(4-pyrid-yl)-1,3-oxazol-2-amine.

Koch P, Schollmeyer D, Laufer S. Koch P, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 Mar 24;66(Pt 4):o917. doi: 10.1107/S1600536810009189. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21580727 Free PMC article.

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