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Page 1
Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.
Smeenk L, Ottema S, Mulet-Lazaro R, Ebert A, Havermans M, Varea AA, Fellner M, Pastoors D, van Herk S, Erpelinck-Verschueren C, Grob T, Hoogenboezem RM, Kavelaars FG, Matson DR, Bresnick EH, Bindels EM, Kentsis A, Zuber J, Delwel R. Smeenk L, et al. Cancer Discov. 2021 Nov;11(11):2868-2883. doi: 10.1158/2159-8290.CD-20-1793. Epub 2021 May 12. Cancer Discov. 2021. PMID: 33980539 Free PMC article.
The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops.
Ottema S, Mulet-Lazaro R, Erpelinck-Verschueren C, van Herk S, Havermans M, Arricibita Varea A, Vermeulen M, Beverloo HB, Gröschel S, Haferlach T, Haferlach C, J Wouters B, Bindels E, Smeenk L, Delwel R. Ottema S, et al. Nat Commun. 2021 Sep 28;12(1):5679. doi: 10.1038/s41467-021-25862-3. Nat Commun. 2021. PMID: 34584081 Free PMC article.
Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.
Tanaka A, Nakano TA, Nomura M, Yamazaki H, Bewersdorf JP, Mulet-Lazaro R, Hogg S, Liu B, Penson A, Yokoyama A, Zang W, Havermans M, Koizumi M, Hayashi Y, Cho H, Kanai A, Lee SC, Xiao M, Koike Y, Zhang Y, Fukumoto M, Aoyama Y, Konuma T, Kunimoto H, Inaba T, Nakajima H, Honda H, Kawamoto H, Delwel R, Abdel-Wahab O, Inoue D. Tanaka A, et al. Among authors: mulet lazaro r. Blood. 2022 Aug 25;140(8):875-888. doi: 10.1182/blood.2021015325. Blood. 2022. PMID: 35709354 Free PMC article.
CEBPA mutations in 4708 patients with acute myeloid leukemia: differential impact of bZIP and TAD mutations on outcome.
Taube F, Georgi JA, Kramer M, Stasik S, Middeke JM, Röllig C, Krug U, Krämer A, Scholl S, Hochhaus A, Brümmendorf TH, Naumann R, Petzold A, Mulet-Lazaro R, Valk PJM, Steffen B, Einsele H, Schaich M, Burchert A, Neubauer A, Schäfer-Eckart K, Schliemann C, Krause SW, Hänel M, Noppeney R, Kaiser U, Baldus CD, Kaufmann M, Herold S, Stölzel F, Sockel K, von Bonin M, Müller-Tidow C, Platzbecker U, Berdel WE, Serve H, Ehninger G, Bornhäuser M, Schetelig J, Thiede C; Study Alliance Leukemia (SAL). Taube F, et al. Blood. 2022 Jan 6;139(1):87-103. doi: 10.1182/blood.2020009680. Blood. 2022. PMID: 34320176 Free article.
Aberrant DNA methylation patterns in microsatellite stable human colorectal cancers define a new marker panel for the CpG island methylator phenotype.
Gebhard C, Mulet-Lazaro R, Glatz D, Schwarzfischer-Pfeilschifter L, Schirmacher P, Gaedcke J, Weichert W, Reuschel E, Dietmaier W, Rehli M. Gebhard C, et al. Among authors: mulet lazaro r. Int J Cancer. 2022 Feb 15;150(4):617-625. doi: 10.1002/ijc.33831. Epub 2021 Oct 13. Int J Cancer. 2022. PMID: 34591983
Oncogenic Enhancers in Leukemia.
Mulet-Lazaro R, Delwel R. Mulet-Lazaro R, et al. Blood Cancer Discov. 2024 Sep 3;5(5):303-317. doi: 10.1158/2643-3230.BCD-23-0211. Blood Cancer Discov. 2024. PMID: 39093124 Review.
15 results