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DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells.
Cueto FJ, Del Fresno C, Brandi P, Combes AJ, Hernández-García E, Sánchez-Paulete AR, Enamorado M, Bromley CP, Gomez MJ, Conde-Garrosa R, Mañes S, Zelenay S, Melero I, Iborra S, Krummel MF, Sancho D. Cueto FJ, et al. Among authors: melero i. J Immunother Cancer. 2021 May;9(5):e002054. doi: 10.1136/jitc-2020-002054. J Immunother Cancer. 2021. PMID: 33980589 Free PMC article.
Dendritic cells delivered inside human carcinomas are sequestered by interleukin-8.
Feijoó E, Alfaro C, Mazzolini G, Serra P, Peñuelas I, Arina A, Huarte E, Tirapu I, Palencia B, Murillo O, Ruiz J, Sangro B, Richter JA, Prieto J, Melero I. Feijoó E, et al. Among authors: melero i. Int J Cancer. 2005 Aug 20;116(2):275-81. doi: 10.1002/ijc.21046. Int J Cancer. 2005. PMID: 15800914 Free article. Clinical Trial.
Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma.
Tirapu I, Huarte E, Guiducci C, Arina A, Zaratiegui M, Murillo O, Gonzalez A, Berasain C, Berraondo P, Fortes P, Prieto J, Colombo MP, Chen L, Melero I. Tirapu I, et al. Among authors: melero i. Cancer Res. 2006 Feb 15;66(4):2442-50. doi: 10.1158/0008-5472.CAN-05-1681. Cancer Res. 2006. PMID: 16489051 Free article.
Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ.
Dubrot J, Milheiro F, Alfaro C, Palazón A, Martinez-Forero I, Perez-Gracia JL, Morales-Kastresana A, Romero-Trevejo JL, Ochoa MC, Hervás-Stubbs S, Prieto J, Jure-Kunkel M, Chen L, Melero I. Dubrot J, et al. Among authors: melero i. Cancer Immunol Immunother. 2010 Aug;59(8):1223-33. doi: 10.1007/s00262-010-0846-9. Epub 2010 Mar 25. Cancer Immunol Immunother. 2010. PMID: 20336294 Free PMC article.
Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells.
Dubrot J, Portero A, Orive G, Hernández RM, Palazón A, Rouzaut A, Perez-Gracia JL, Hervás-Stubbs S, Pedraz JL, Melero I. Dubrot J, et al. Among authors: melero i. Cancer Immunol Immunother. 2010 Nov;59(11):1621-31. doi: 10.1007/s00262-010-0888-z. Epub 2010 Jul 6. Cancer Immunol Immunother. 2010. PMID: 20607237 Free PMC article.
Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes.
Palazón A, Teijeira A, Martínez-Forero I, Hervás-Stubbs S, Roncal C, Peñuelas I, Dubrot J, Morales-Kastresana A, Pérez-Gracia JL, Ochoa MC, Ochoa-Callejero L, Martínez A, Luque A, Dinchuk J, Rouzaut A, Jure-Kunkel M, Melero I. Palazón A, et al. Among authors: melero i. Cancer Res. 2011 Feb 1;71(3):801-11. doi: 10.1158/0008-5472.CAN-10-1733. Epub 2011 Jan 25. Cancer Res. 2011. PMID: 21266358
The HIF-1α hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy.
Palazón A, Martínez-Forero I, Teijeira A, Morales-Kastresana A, Alfaro C, Sanmamed MF, Perez-Gracia JL, Peñuelas I, Hervás-Stubbs S, Rouzaut A, de Landázuri MO, Jure-Kunkel M, Aragonés J, Melero I. Palazón A, et al. Among authors: melero i. Cancer Discov. 2012 Jul;2(7):608-23. doi: 10.1158/2159-8290.CD-11-0314. Epub 2012 Jun 19. Cancer Discov. 2012. PMID: 22719018
373 results