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An aged immune system drives senescence and ageing of solid organs.
Yousefzadeh MJ, Flores RR, Zhu Y, Schmiechen ZC, Brooks RW, Trussoni CE, Cui Y, Angelini L, Lee KA, McGowan SJ, Burrack AL, Wang D, Dong Q, Lu A, Sano T, O'Kelly RD, McGuckian CA, Kato JI, Bank MP, Wade EA, Pillai SPS, Klug J, Ladiges WC, Burd CE, Lewis SE, LaRusso NF, Vo NV, Wang Y, Kelley EE, Huard J, Stromnes IM, Robbins PD, Niedernhofer LJ. Yousefzadeh MJ, et al. Among authors: ladiges wc. Nature. 2021 Jun;594(7861):100-105. doi: 10.1038/s41586-021-03547-7. Epub 2021 May 12. Nature. 2021. PMID: 33981041 Free PMC article.
A New Preclinical Paradigm for Testing Anti-Aging Therapeutics.
Ladiges W, Snyder JM, Wilkinson E, Imai DM, Snider T, Ge X, Ciol M, Pettan-Brewer C, Pillai SPS, Morton J, Quarles E, Rabinovitch P, Niedernhofer L, Liggitt D. Ladiges W, et al. J Gerontol A Biol Sci Med Sci. 2017 Jun 1;72(6):760-762. doi: 10.1093/gerona/glx019. J Gerontol A Biol Sci Med Sci. 2017. PMID: 28329081 Free PMC article.
Modeling Alzheimer's disease in progeria mice. An age-related concept.
Sharma K, Darvas M, Keene CD, Niedernhofer LJ, Ladiges W. Sharma K, et al. Pathobiol Aging Age Relat Dis. 2018 Oct 4;8(1):1524815. doi: 10.1080/20010001.2018.1524815. eCollection 2018. Pathobiol Aging Age Relat Dis. 2018. PMID: 30319737 Free PMC article.
Measuring biological age in mice using differential mass spectrometry.
Bell-Temin H, Yousefzadeh MJ, Bondarenko A, Quarles E, Jones-Laughner J, Robbins PD, Ladiges W, Niedernhofer LJ, Yates NA. Bell-Temin H, et al. Aging (Albany NY). 2019 Feb 11;11(3):1045-1061. doi: 10.18632/aging.101810. Aging (Albany NY). 2019. PMID: 30745468 Free PMC article.
Validation of a geropathology grading system for aging mouse studies.
Snyder JM, Snider TA, Ciol MA, Wilkinson JE, Imai DM, Casey KM, Vilches-Moure JG, Pettan-Brewer C, Pillai SPS, Carrasco SE, Salimi S, Ladiges W. Snyder JM, et al. Geroscience. 2019 Aug;41(4):455-465. doi: 10.1007/s11357-019-00088-w. Epub 2019 Aug 29. Geroscience. 2019. PMID: 31468322 Free PMC article.
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, Scibetta A, Yousefzadeh MJ, Li X, Gurkar AU, McGowan SJ, Angelini L, O'Kelly R, Li H, Corbo L, Sano T, Nick H, Pola E, Pilla SPS, Ladiges WC, Vo N, Huard J, Niedernhofer LJ, Robbins PD. Zhao J, et al. Among authors: ladiges wc. Aging (Albany NY). 2020 Mar 22;12(6):4688-4710. doi: 10.18632/aging.102863. Epub 2020 Mar 22. Aging (Albany NY). 2020. PMID: 32201398 Free PMC article.
Genetics of extreme human longevity to guide drug discovery for healthy ageing.
Zhang ZD, Milman S, Lin JR, Wierbowski S, Yu H, Barzilai N, Gorbunova V, Ladiges WC, Niedernhofer LJ, Suh Y, Robbins PD, Vijg J. Zhang ZD, et al. Among authors: ladiges wc. Nat Metab. 2020 Aug;2(8):663-672. doi: 10.1038/s42255-020-0247-0. Epub 2020 Jul 27. Nat Metab. 2020. PMID: 32719537 Free PMC article. Review.
189 results