Lane JR - Search Results

1

Novel Dual-Target μ-Opioid Receptor and Dopamine D₃ Receptor Ligands as Potential Nonaddictive Pharmacotherapeutics for Pain Management.

Bonifazi A, Battiti FO, Sanchez J, Zaidi SA, Bow E, Makarova M, Cao J, Shaik AB, Sulima A, Rice KC, Katritch V, Canals M, Lane JR, Newman AH. Bonifazi A, et al. Among authors: lane jr. J Med Chem. 2021 Jun 10;64(11):7778-7808. doi: 10.1021/acs.jmedchem.1c00611. Epub 2021 May 20. J Med Chem. 2021. PMID: 34011153 Free PMC article.

2

Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.

Katritch V, Jaakola VP, Lane JR, Lin J, Ijzerman AP, Yeager M, Kufareva I, Stevens RC, Abagyan R. Katritch V, et al. Among authors: lane jr. J Med Chem. 2010 Feb 25;53(4):1799-809. doi: 10.1021/jm901647p. J Med Chem. 2010. PMID: 20095623 Free PMC article.

3

Ligand binding and subtype selectivity of the human A(2A) adenosine receptor: identification and characterization of essential amino acid residues.

Jaakola VP, Lane JR, Lin JY, Katritch V, Ijzerman AP, Stevens RC. Jaakola VP, et al. Among authors: lane jr. J Biol Chem. 2010 Apr 23;285(17):13032-44. doi: 10.1074/jbc.M109.096974. Epub 2010 Feb 10. J Biol Chem. 2010. PMID: 20147292 Free PMC article.

4

Hybrid ortho/allosteric ligands for the adenosine A(1) receptor.

Narlawar R, Lane JR, Doddareddy M, Lin J, Brussee J, Ijzerman AP. Narlawar R, et al. Among authors: lane jr. J Med Chem. 2010 Apr 22;53(8):3028-37. doi: 10.1021/jm901252a. J Med Chem. 2010. PMID: 20345101

5

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation.

Canals M, Lane JR, Wen A, Scammells PJ, Sexton PM, Christopoulos A. Canals M, et al. Among authors: lane jr. J Biol Chem. 2012 Jan 2;287(1):650-659. doi: 10.1074/jbc.M111.314278. Epub 2011 Nov 15. J Biol Chem. 2012. PMID: 22086918 Free PMC article.

6

Homobivalent ligands of the atypical antipsychotic clozapine: design, synthesis, and pharmacological evaluation.

McRobb FM, Crosby IT, Yuriev E, Lane JR, Capuano B. McRobb FM, et al. Among authors: lane jr. J Med Chem. 2012 Feb 23;55(4):1622-34. doi: 10.1021/jm201420s. Epub 2012 Feb 2. J Med Chem. 2012. PMID: 22243698

7

Novel 3,6,7-substituted pyrazolopyrimidines as positive allosteric modulators for the hydroxycarboxylic acid receptor 2 (GPR109A).

Blad CC, van Veldhoven JP, Klopman C, Wolfram DR, Brussee J, Lane JR, Ijzerman AP. Blad CC, et al. Among authors: lane jr. J Med Chem. 2012 Apr 12;55(7):3563-7. doi: 10.1021/jm300164q. Epub 2012 Mar 27. J Med Chem. 2012. PMID: 22420767

8

A prospective cross-screening study on G-protein-coupled receptors: lessons learned in virtual compound library design.

Sanders MP, Roumen L, van der Horst E, Lane JR, Vischer HF, van Offenbeek J, de Vries H, Verhoeven S, Chow KY, Verkaar F, Beukers MW, McGuire R, Leurs R, Ijzerman AP, de Vlieg J, de Esch IJ, Zaman GJ, Klomp JP, Bender A, de Graaf C. Sanders MP, et al. Among authors: lane jr. J Med Chem. 2012 Jun 14;55(11):5311-25. doi: 10.1021/jm300280e. Epub 2012 May 23. J Med Chem. 2012. PMID: 22563707

9

Sequential conformational rearrangements dictate the dynamics of class C GPCR activation.

Lane JR, Canals M. Lane JR, et al. Sci Signal. 2012 Nov 20;5(251):pe51. doi: 10.1126/scisignal.2003503. Sci Signal. 2012. PMID: 23169816

10

Allosteric modulation of a chemogenetically modified G protein-coupled receptor.

Abdul-Ridha A, Lane JR, Sexton PM, Canals M, Christopoulos A. Abdul-Ridha A, et al. Among authors: lane jr. Mol Pharmacol. 2013 Feb;83(2):521-30. doi: 10.1124/mol.112.083006. Epub 2012 Nov 29. Mol Pharmacol. 2013. PMID: 23197649

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