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Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies.
Rouet R, Mazigi O, Walker GJ, Langley DB, Sobti M, Schofield P, Lenthall H, Jackson J, Ubiparipovic S, Henry JY, Abayasingam A, Burnett D, Kelleher A, Brink R, Bull RA, Turville S, Stewart AG, Goodnow CC, Rawlinson WD, Christ D. Rouet R, et al. Among authors: schofield p. MAbs. 2021 Jan-Dec;13(1):1922134. doi: 10.1080/19420862.2021.1922134. MAbs. 2021. PMID: 34024246 Free PMC article.
Aggregation, stability, and formulation of human antibody therapeutics.
Lowe D, Dudgeon K, Rouet R, Schofield P, Jermutus L, Christ D. Lowe D, et al. Among authors: schofield p. Adv Protein Chem Struct Biol. 2011;84:41-61. doi: 10.1016/B978-0-12-386483-3.00004-5. Adv Protein Chem Struct Biol. 2011. PMID: 21846562 Review.
Expression of high-affinity human antibody fragments in bacteria.
Rouet R, Lowe D, Dudgeon K, Roome B, Schofield P, Langley D, Andrews J, Whitfeld P, Jermutus L, Christ D. Rouet R, et al. Among authors: schofield p. Nat Protoc. 2012 Feb 2;7(2):364-73. doi: 10.1038/nprot.2011.448. Nat Protoc. 2012. PMID: 22301775
Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.
Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan TD, Brink R, Dunn-Walters DK, Christ D, Goodnow CC. Sabouri Z, et al. Among authors: schofield p. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12. Proc Natl Acad Sci U S A. 2014. PMID: 24821781 Free PMC article. Clinical Trial.
FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.
Butt D, Chan TD, Bourne K, Hermes JR, Nguyen A, Statham A, O'Reilly LA, Strasser A, Price S, Schofield P, Christ D, Basten A, Ma CS, Tangye SG, Phan TG, Rao VK, Brink R. Butt D, et al. Among authors: schofield p. Immunity. 2015 May 19;42(5):890-902. doi: 10.1016/j.immuni.2015.04.010. Epub 2015 May 12. Immunity. 2015. PMID: 25979420 Free article.
Circumventing the stability-function trade-off in an engineered FN3 domain.
Porebski BT, Conroy PJ, Drinkwater N, Schofield P, Vazquez-Lombardi R, Hunter MR, Hoke DE, Christ D, McGowan S, Buckle AM. Porebski BT, et al. Among authors: schofield p. Protein Eng Des Sel. 2016 Nov 1;29(11):541-550. doi: 10.1093/protein/gzw046. Protein Eng Des Sel. 2016. PMID: 27578887 Free PMC article.
Structural reconstruction of protein ancestry.
Rouet R, Langley DB, Schofield P, Christie M, Roome B, Porebski BT, Buckle AM, Clifton BE, Jackson CJ, Stock D, Christ D. Rouet R, et al. Among authors: schofield p. Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3897-3902. doi: 10.1073/pnas.1613477114. Epub 2017 Mar 29. Proc Natl Acad Sci U S A. 2017. PMID: 28356519 Free PMC article.
1,835 results