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Page 1
Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.
Grand DL, Gosling M, Baettig U, Bahra P, Bala K, Brocklehurst C, Budd E, Butler R, Cheung AK, Choudhury H, Collingwood SP, Cox B, Danahay H, Edwards L, Everatt B, Glaenzel U, Glotin AL, Groot-Kormelink P, Hall E, Hatto J, Howsham C, Hughes G, King A, Koehler J, Kulkarni S, Lightfoot M, Nicholls I, Page C, Pergl-Wilson G, Popa MO, Robinson R, Rowlands D, Sharp T, Spendiff M, Stanley E, Steward O, Taylor RJ, Tranter P, Wagner T, Watson H, Williams G, Wright P, Young A, Sandham DA. Grand DL, et al. Among authors: spendiff m. J Med Chem. 2021 Jun 10;64(11):7241-7260. doi: 10.1021/acs.jmedchem.1c00343. Epub 2021 May 24. J Med Chem. 2021. PMID: 34028270
Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ.
Bellenie BR, Hall E, Bruce I, Spendiff M, Culshaw A, McDonald S, Ambarkhane A, Chinn C, Thomas M, Rosner E, Bracher M, Nicklin P, Marshall S, Coote J, Cullen E, Tessier C, Wuersch K, Lal A, Wallis G, Hollingworth GJ, Neef J. Bellenie BR, et al. Among authors: spendiff m. J Med Chem. 2021 Aug 26;64(16):12304-12321. doi: 10.1021/acs.jmedchem.1c00986. Epub 2021 Aug 12. J Med Chem. 2021. PMID: 34384024
Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: the first steps.
Loizou G, Spendiff M, Barton HA, Bessems J, Bois FY, d'Yvoire MB, Buist H, Clewell HJ 3rd, Meek B, Gundert-Remy U, Goerlitz G, Schmitt W. Loizou G, et al. Among authors: spendiff m. Regul Toxicol Pharmacol. 2008 Apr;50(3):400-11. doi: 10.1016/j.yrtph.2008.01.011. Epub 2008 Feb 1. Regul Toxicol Pharmacol. 2008. PMID: 18331772 Free article. Review.
Physiologically-based Kinetic Modelling (PBK Modelling): meeting the 3Rs agenda. The report and recommendations of ECVAM Workshop 63.
Bouvier d'Yvoire M, Prieto P, Blaauboer BJ, Bois FY, Boobis A, Brochot C, Coecke S, Freidig A, Gundert-Remy U, Hartung T, Jacobs MN, Lavé T, Leahy DE, Lennernäs H, Loizou GD, Meek B, Pease C, Rowland M, Spendiff M, Yang J, Zeilmaker M. Bouvier d'Yvoire M, et al. Among authors: spendiff m. Altern Lab Anim. 2007 Dec;35(6):661-71. doi: 10.1177/026119290703500606. Altern Lab Anim. 2007. PMID: 18186671 No abstract available.
Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation.
Barton HA, Chiu WA, Setzer RW, Andersen ME, Bailer AJ, Bois FY, Dewoskin RS, Hays S, Johanson G, Jones N, Loizou G, Macphail RC, Portier CJ, Spendiff M, Tan YM. Barton HA, et al. Among authors: spendiff m. Toxicol Sci. 2007 Oct;99(2):395-402. doi: 10.1093/toxsci/kfm100. Epub 2007 May 4. Toxicol Sci. 2007. PMID: 17483121
Case Study Part 1: How to calculate appropriate deterministic long-term toxicity to exposure ratios (TERs) for birds and mammals.
Shore RF, Crocker DR, Akcakaya HR, Bennett RS, Chapman PF, Clook M, Crane M, Dewhurst IC, Edwards PJ, Fairbrother A, Ferson S, Fischer D, Hart AD, Holmes M, Hooper MJ, Lavine M, Leopold A, Luttik R, Mineau P, Moore DR, Mortenson SR, Noble DG, O'Connor RJ, Roelofs W, Sibly RM, Smith GC, Spendiff M, Springer TA, Thompson HM, Topping C. Shore RF, et al. Among authors: spendiff m. Ecotoxicology. 2005 Nov;14(8):877-93. doi: 10.1007/s10646-005-0034-4. Epub 2005 Nov 23. Ecotoxicology. 2005. PMID: 16328715
Case Study Part 2: Probabilistic modelling of long-term effects of pesticides on individual breeding success in birds and mammals.
Roelofs W, Crocker DR, Shore RF, Moore DR, Smith GC, Akcakaya HR, Bennett RS, Chapman PF, Clook M, Crane M, Dewhurst IC, Edwards PJ, Fairbrother A, Ferson S, Fischer D, Hart AD, Holmes M, Hooper MJ, Lavine M, Leopold A, Luttik R, Mineau P, Mortenson SR, Noble DG, O'Connor RJ, Sibly RM, Spendiff M, Springer TA, Thompson HM, Topping C. Roelofs W, et al. Among authors: spendiff m. Ecotoxicology. 2005 Nov;14(8):895-923. doi: 10.1007/s10646-005-0035-3. Epub 2005 Nov 23. Ecotoxicology. 2005. PMID: 16328714