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Short N-terminal disordered regions and the proline-rich domain are major regulators of phase transitions for full-length UBQLN1, UBQLN2 and UBQLN4.
Dao TP, Rajendran A, Galagedera SKK, Haws W, Castañeda CA. Dao TP, et al. Among authors: galagedera skk. bioRxiv [Preprint]. 2023 Sep 29:2023.09.27.559790. doi: 10.1101/2023.09.27.559790. bioRxiv. 2023. Update in: Biophys J. 2024 Jun 4;123(11):1449-1457. doi: 10.1016/j.bpj.2023.11.3401 PMID: 37808720 Free PMC article. Updated. Preprint.
Phase separation of polyubiquitinated proteins in UBQLN2 condensates controls substrate fate.
Valentino IM, Llivicota-Guaman JG, Dao TP, Mulvey EO, Lehman AM, Galagedera SKK, Mallon EL, Castañeda CA, Kraut DA. Valentino IM, et al. Among authors: galagedera skk. bioRxiv [Preprint]. 2024 Jun 20:2024.03.15.585243. doi: 10.1101/2024.03.15.585243. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 Aug 13;121(33):e2405964121. doi: 10.1073/pnas.2405964121 PMID: 38559018 Free PMC article. Updated. Preprint.