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Oxidative DNA damage stalls the human mitochondrial replisome.
Stojkovič G, Makarova AV, Wanrooij PH, Forslund J, Burgers PM, Wanrooij S. Stojkovič G, et al. Among authors: wanrooij s, wanrooij ph. Sci Rep. 2016 Jul 1;6:28942. doi: 10.1038/srep28942. Sci Rep. 2016. PMID: 27364318 Free PMC article.
DNA Damage Tolerance by Eukaryotic DNA Polymerase and Primase PrimPol.
Boldinova EO, Wanrooij PH, Shilkin ES, Wanrooij S, Makarova AV. Boldinova EO, et al. Among authors: wanrooij s, wanrooij ph. Int J Mol Sci. 2017 Jul 21;18(7):1584. doi: 10.3390/ijms18071584. Int J Mol Sci. 2017. PMID: 28754021 Free PMC article. Review.
PrimPol is required for replication reinitiation after mtDNA damage.
Torregrosa-Muñumer R, Forslund JME, Goffart S, Pfeiffer A, Stojkovič G, Carvalho G, Al-Furoukh N, Blanco L, Wanrooij S, Pohjoismäki JLO. Torregrosa-Muñumer R, et al. Among authors: wanrooij s. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11398-11403. doi: 10.1073/pnas.1705367114. Epub 2017 Oct 9. Proc Natl Acad Sci U S A. 2017. PMID: 29073063 Free PMC article.
The presence of rNTPs decreases the speed of mitochondrial DNA replication.
Forslund JME, Pfeiffer A, Stojkovič G, Wanrooij PH, Wanrooij S. Forslund JME, et al. Among authors: wanrooij s, wanrooij ph. PLoS Genet. 2018 Mar 30;14(3):e1007315. doi: 10.1371/journal.pgen.1007315. eCollection 2018 Mar. PLoS Genet. 2018. PMID: 29601571 Free PMC article.
Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization.
Jamroskovic J, Doimo M, Chand K, Obi I, Kumar R, Brännström K, Hedenström M, Nath Das R, Akhunzianov A, Deiana M, Kasho K, Sulis Sato S, Pourbozorgi PL, Mason JE, Medini P, Öhlund D, Wanrooij S, Chorell E, Sabouri N. Jamroskovic J, et al. Among authors: wanrooij s. J Am Chem Soc. 2020 Feb 12;142(6):2876-2888. doi: 10.1021/jacs.9b11232. Epub 2020 Jan 28. J Am Chem Soc. 2020. PMID: 31990532 Free PMC article.
TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication.
Inatomi T, Matsuda S, Ishiuchi T, Do Y, Nakayama M, Abe S, Kasho K, Wanrooij S, Nakada K, Ichiyanagi K, Sasaki H, Yasukawa T, Kang D. Inatomi T, et al. Among authors: wanrooij s. Biochim Biophys Acta Mol Cell Res. 2022 Jan;1869(1):119167. doi: 10.1016/j.bbamcr.2021.119167. Epub 2021 Oct 30. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 34744028 Free article.
42 results