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Genetic and biological hallmarks of colorectal cancer.
Li J, Ma X, Chakravarti D, Shalapour S, DePinho RA. Li J, et al. Among authors: depinho ra. Genes Dev. 2021 Jun;35(11-12):787-820. doi: 10.1101/gad.348226.120. Genes Dev. 2021. PMID: 34074695 Free PMC article. Review.
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase.
Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG Jr, Zhang Q. Zheng X, et al. Among authors: depinho ra. Genes Dev. 2014 Jul 1;28(13):1429-44. doi: 10.1101/gad.242131.114. Genes Dev. 2014. PMID: 24990963 Free PMC article.
Genetics and biology of pancreatic ductal adenocarcinoma.
Ying H, Dey P, Yao W, Kimmelman AC, Draetta GF, Maitra A, DePinho RA. Ying H, et al. Among authors: depinho ra. Genes Dev. 2016 Feb 15;30(4):355-85. doi: 10.1101/gad.275776.115. Genes Dev. 2016. PMID: 26883357 Free PMC article. Review.
Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.
Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, Liang X, Chen JR, Shah S, Shang X, Tang M, Deng P, Dey P, Chakravarti D, Chen P, Spring DJ, Navone NM, Troncoso P, Zhang J, Wang YA, DePinho RA. Zhao D, et al. Among authors: depinho ra. Nature. 2017 Feb 23;542(7642):484-488. doi: 10.1038/nature21357. Epub 2017 Feb 6. Nature. 2017. PMID: 28166537 Free PMC article.
Oncogenic Kras drives invasion and maintains metastases in colorectal cancer.
Boutin AT, Liao WT, Wang M, Hwang SS, Karpinets TV, Cheung H, Chu GC, Jiang S, Hu J, Chang K, Vilar E, Song X, Zhang J, Kopetz S, Futreal A, Wang YA, Kwong LN, DePinho RA. Boutin AT, et al. Among authors: depinho ra. Genes Dev. 2017 Feb 15;31(4):370-382. doi: 10.1101/gad.293449.116. Epub 2017 Mar 13. Genes Dev. 2017. PMID: 28289141 Free PMC article.
PRKCI promotes immune suppression in ovarian cancer.
Sarkar S, Bristow CA, Dey P, Rai K, Perets R, Ramirez-Cardenas A, Malasi S, Huang-Hobbs E, Haemmerle M, Wu SY, McGuire M, Protopopov A, Jiang S, Liu JF, Hirsch MS, Chang Q, Lazar AJ, Sood AK, Drapkin R, DePinho R, Draetta G, Chin L. Sarkar S, et al. Genes Dev. 2017 Jun 1;31(11):1109-1121. doi: 10.1101/gad.296640.117. Epub 2017 Jul 11. Genes Dev. 2017. PMID: 28698296 Free PMC article.
Opposing roles of TGFβ and BMP signaling in prostate cancer development.
Lu X, Jin EJ, Cheng X, Feng S, Shang X, Deng P, Jiang S, Chang Q, Rahmy S, Chaudhary S, Lu X, Zhao R, Wang YA, DePinho RA. Lu X, et al. Among authors: depinho ra. Genes Dev. 2017 Dec 1;31(23-24):2337-2342. doi: 10.1101/gad.307116.117. Genes Dev. 2017. PMID: 29352019 Free PMC article.
Genetics and biology of prostate cancer.
Wang G, Zhao D, Spring DJ, DePinho RA. Wang G, et al. Among authors: depinho ra. Genes Dev. 2018 Sep 1;32(17-18):1105-1140. doi: 10.1101/gad.315739.118. Genes Dev. 2018. PMID: 30181359 Free PMC article. Review.
KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer.
Liao W, Overman MJ, Boutin AT, Shang X, Zhao D, Dey P, Li J, Wang G, Lan Z, Li J, Tang M, Jiang S, Ma X, Chen P, Katkhuda R, Korphaisarn K, Chakravarti D, Chang A, Spring DJ, Chang Q, Zhang J, Maru DM, Maeda DY, Zebala JA, Kopetz S, Wang YA, DePinho RA. Liao W, et al. Among authors: depinho ra. Cancer Cell. 2019 Apr 15;35(4):559-572.e7. doi: 10.1016/j.ccell.2019.02.008. Epub 2019 Mar 21. Cancer Cell. 2019. PMID: 30905761 Free PMC article.
469 results