O'Shea JJ - Search Results

1

Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus.

Hasni SA, Gupta S, Davis M, Poncio E, Temesgen-Oyelakin Y, Carlucci PM, Wang X, Naqi M, Playford MP, Goel RR, Li X, Biehl AJ, Ochoa-Navas I, Manna Z, Shi Y, Thomas D, Chen J, Biancotto A, Apps R, Cheung F, Kotliarov Y, Babyak AL, Zhou H, Shi R, Stagliano K, Tsai WL, Vian L, Gazaniga N, Giudice V, Lu S, Brooks SR, MacKay M, Gregersen P, Mehta NN, Remaley AT, Diamond B, O'Shea JJ, Gadina M, Kaplan MJ. Hasni SA, et al. Nat Commun. 2021 Jun 7;12(1):3391. doi: 10.1038/s41467-021-23361-z. Nat Commun. 2021. PMID: 34099646 Free PMC article. Clinical Trial.

2

Involvement of SHP-2 in multiple aspects of IL-2 signaling: evidence for a positive regulatory role.

Gadina M, Stancato LM, Bacon CM, Larner AC, O'Shea JJ. Gadina M, et al. J Immunol. 1998 May 15;160(10):4657-61. J Immunol. 1998. PMID: 9590209

3

Not just another meeting: the coming of age of JAKs and STATs.

Chen EH, Gadina M, Galon J, Chen M, O'Shea JJ. Chen EH, et al. Immunol Today. 1998 Aug;19(8):338-41. doi: 10.1016/s0167-5699(98)01295-x. Immunol Today. 1998. PMID: 9709499 Review. No abstract available.

4

IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2.

Gadina M, Sudarshan C, O'Shea JJ. Gadina M, et al. J Immunol. 1999 Feb 15;162(4):2081-6. J Immunol. 1999. PMID: 9973481

5

Advances in cytokine signaling: the role of Jaks and STATs.

Chen E, Gadina M, Chen M, O'Shea JJ. Chen E, et al. Transplant Proc. 1999 May;31(3):1482-7. doi: 10.1016/s0041-1345(99)00013-5. Transplant Proc. 1999. PMID: 10330976 Review. No abstract available.

6

Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes.

Franchimont D, Galon J, Gadina M, Visconti R, Zhou Y, Aringer M, Frucht DM, Chrousos GP, O'Shea JJ. Franchimont D, et al. J Immunol. 2000 Feb 15;164(4):1768-74. doi: 10.4049/jimmunol.164.4.1768. J Immunol. 2000. PMID: 10657623

7

Cytokine regulation of IL-12 receptor beta2 expression: differential effects on human T and NK cells.

Wu CY, Gadina M, Wang K, O'Shea J, Seder RA. Wu CY, et al. Eur J Immunol. 2000 May;30(5):1364-74. doi: 10.1002/(SICI)1521-4141(200005)30:5<1364::AID-IMMU1364>3.0.CO;2-U. Eur J Immunol. 2000. PMID: 10820383 Free article.

8

Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity.

Visconti R, Gadina M, Chiariello M, Chen EH, Stancato LF, Gutkind JS, O'Shea JJ. Visconti R, et al. Blood. 2000 Sep 1;96(5):1844-52. Blood. 2000. PMID: 10961885 Free article.

9

Jaks and stats as therapeutic targets.

O'Shea JJ, Visconti R, Cheng TP, Gadina M. O'Shea JJ, et al. Ann Rheum Dis. 2000 Nov;59 Suppl 1(Suppl 1):i115-8. doi: 10.1136/ard.59.suppl_1.i115. Ann Rheum Dis. 2000. PMID: 11053101 Free PMC article. Review.

10

IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites.

Wu C, Wang X, Gadina M, O'Shea JJ, Presky DH, Magram J. Wu C, et al. J Immunol. 2000 Dec 1;165(11):6221-8. doi: 10.4049/jimmunol.165.11.6221. J Immunol. 2000. PMID: 11086056

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