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High-dose Mycobacterium tuberculosis aerosol challenge cannot overcome BCG-induced protection in Chinese origin cynomolgus macaques; implications of natural resistance for vaccine evaluation.
Sibley L, White AD, Gooch KE, Stevens LM, Tanner R, Jacobs A, Daykin-Pont O, Gleeson F, McIntyre A, Basaraba R, Clark S, Hall G, Pearson G, Rayner E, McShane H, Williams A, Dennis M, Marsh PD, Sharpe S. Sibley L, et al. Among authors: williams a. Sci Rep. 2021 Jun 10;11(1):12274. doi: 10.1038/s41598-021-90913-0. Sci Rep. 2021. PMID: 34112845 Free PMC article.
Identification of a Mycobacterium bovis BCG auxotrophic mutant that protects guinea pigs against M. bovis and hematogenous spread of Mycobacterium tuberculosis without sensitization to tuberculin.
Chambers MA, Williams A, Gavier-Widén D, Whelan A, Hall G, Marsh PD, Bloom BR, Jacobs WR, Hewinson RG. Chambers MA, et al. Among authors: williams a. Infect Immun. 2000 Dec;68(12):7094-9. doi: 10.1128/IAI.68.12.7094-7099.2000. Infect Immun. 2000. PMID: 11083835 Free PMC article.
A guinea pig model of low-dose Mycobacterium bovis aerogenic infection.
Chambers MA, Williams A, Gavier-Widén D, Whelan A, Hughes C, Hall G, Lever MS, Marsh PD, Hewinson RG. Chambers MA, et al. Among authors: williams a. Vet Microbiol. 2001 Jun 6;80(3):213-26. doi: 10.1016/s0378-1135(00)00378-3. Vet Microbiol. 2001. PMID: 11337137
Vaccination of guinea pigs with DNA encoding the mycobacterial antigen MPB83 influences pulmonary pathology but not hematogenous spread following aerogenic infection with Mycobacterium bovis.
Chambers MA, Williams A, Hatch G, Gavier-Widén D, Hall G, Huygen K, Lowrie D, Marsh PD, Hewinson RG. Chambers MA, et al. Among authors: williams a. Infect Immun. 2002 Apr;70(4):2159-65. doi: 10.1128/IAI.70.4.2159-2165.2002. Infect Immun. 2002. PMID: 11895982 Free PMC article.
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