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The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological drug for the experimental therapy of sepsis.
Ahmad A, Vieira JC, de Mello AH, de Lima TM, Ariga SK, Barbeiro DF, Barbeiro HV, Szczesny B, Törö G, Druzhyna N, Randi EB, Marcatti M, Toliver-Kinsky T, Kiss A, Liaudet L, Salomao R, Soriano FG, Szabo C. Ahmad A, et al. Among authors: soriano fg. Pharmacol Res. 2019 Jul;145:104263. doi: 10.1016/j.phrs.2019.104263. Epub 2019 May 6. Pharmacol Res. 2019. PMID: 31071432 Free PMC article.
Opportunities for the repurposing of PARP inhibitors for the therapy of non-oncological diseases.
Berger NA, Besson VC, Boulares AH, Bürkle A, Chiarugi A, Clark RS, Curtin NJ, Cuzzocrea S, Dawson TM, Dawson VL, Haskó G, Liaudet L, Moroni F, Pacher P, Radermacher P, Salzman AL, Snyder SH, Soriano FG, Strosznajder RP, Sümegi B, Swanson RA, Szabo C. Berger NA, et al. Among authors: soriano fg. Br J Pharmacol. 2018 Jan;175(2):192-222. doi: 10.1111/bph.13748. Epub 2017 Mar 26. Br J Pharmacol. 2018. PMID: 28213892 Free PMC article. Review.
Pathomechanisms of myocardial dysfunction in sepsis.
Lorigados CB, Soriano FG, Szabo C. Lorigados CB, et al. Among authors: soriano fg. Endocr Metab Immune Disord Drug Targets. 2010 Sep;10(3):274-84. doi: 10.2174/187153010791936856. Endocr Metab Immune Disord Drug Targets. 2010. PMID: 20509838 Review.
146 results