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Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets.
Reichmann MT, Tezera LB, Vallejo AF, Vukmirovic M, Xiao R, Reynolds J, Jogai S, Wilson S, Marshall B, Jones MG, Leslie A, D'Armiento JM, Kaminski N, Polak ME, Elkington P. Reichmann MT, et al. Among authors: leslie a. J Clin Invest. 2021 Aug 2;131(15):e148136. doi: 10.1172/JCI148136. J Clin Invest. 2021. PMID: 34128839 Free PMC article.
Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-α.
Tezera LB, Bielecka MK, Ogongo P, Walker NF, Ellis M, Garay-Baquero DJ, Thomas K, Reichmann MT, Johnston DA, Wilkinson KA, Ahmed M, Jogai S, Jayasinghe SN, Wilkinson RJ, Mansour S, Thomas GJ, Ottensmeier CH, Leslie A, Elkington PT. Tezera LB, et al. Among authors: leslie a. Elife. 2020 Feb 24;9:e52668. doi: 10.7554/eLife.52668. Elife. 2020. PMID: 32091388 Free PMC article.
Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung.
Ogongo P, Tezera LB, Ardain A, Nhamoyebonde S, Ramsuran D, Singh A, Ng'oepe A, Karim F, Naidoo T, Khan K, Dullabh KJ, Fehlings M, Lee BH, Nardin A, Lindestam Arlehamn CS, Sette A, Behar SM, Steyn AJ, Madansein R, Kløverpris HN, Elkington PT, Leslie A. Ogongo P, et al. Among authors: leslie a. J Clin Invest. 2021 May 17;131(10):e142014. doi: 10.1172/JCI142014. J Clin Invest. 2021. PMID: 33848273 Free PMC article. Clinical Trial.
Understanding the tuberculosis granuloma: the matrix revolutions.
Elkington P, Polak ME, Reichmann MT, Leslie A. Elkington P, et al. Among authors: leslie a. Trends Mol Med. 2022 Feb;28(2):143-154. doi: 10.1016/j.molmed.2021.11.004. Epub 2021 Dec 15. Trends Mol Med. 2022. PMID: 34922835 Free PMC article. Review.
Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10.
Ahmed M, Mackenzie J, Tezera L, Krause R, Truebody B, Garay-Baquero D, Vallejo A, Govender K, Adamson J, Fisher H, Essex JW, Mansour S, Elkington P, Steyn AJC, Leslie A. Ahmed M, et al. Among authors: leslie a. Commun Biol. 2022 Dec 1;5(1):1317. doi: 10.1038/s42003-022-04265-0. Commun Biol. 2022. PMID: 36456824 Free PMC article.
Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model.
Ahmed M, Tezera LB, Herbert N, Chambers M, Reichmann MT, Nargan K, Kloverpris H, Karim F, Hlatshwayo M, Madensein R, Habesh M, Hoque M, Steyn AJC, Elkington PT, Leslie AJ. Ahmed M, et al. Front Immunol. 2024 Apr 30;15:1360412. doi: 10.3389/fimmu.2024.1360412. eCollection 2024. Front Immunol. 2024. PMID: 38745652 Free PMC article.
496 results