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The common ABCA3E292V variant disrupts AT2 cell quality control and increases susceptibility to lung injury and aberrant remodeling.
Tomer Y, Wambach J, Knudsen L, Zhao M, Rodriguez LR, Murthy A, White FV, Venosa A, Katzen J, Ochs M, Hamvas A, Beers MF, Mulugeta S. Tomer Y, et al. Among authors: katzen j. Am J Physiol Lung Cell Mol Physiol. 2021 Aug 1;321(2):L291-L307. doi: 10.1152/ajplung.00400.2020. Epub 2021 Jun 16. Am J Physiol Lung Cell Mol Physiol. 2021. PMID: 34132118 Free PMC article.
An SFTPC BRICHOS mutant links epithelial ER stress and spontaneous lung fibrosis.
Katzen J, Wagner BD, Venosa A, Kopp M, Tomer Y, Russo SJ, Headen AC, Basil MC, Stark JM, Mulugeta S, Deterding RR, Beers MF. Katzen J, et al. JCI Insight. 2019 Mar 21;4(6):e126125. doi: 10.1172/jci.insight.126125. eCollection 2019 Mar 21. JCI Insight. 2019. PMID: 30721158 Free PMC article.
In utero gene editing for monogenic lung disease.
Alapati D, Zacharias WJ, Hartman HA, Rossidis AC, Stratigis JD, Ahn NJ, Coons B, Zhou S, Li H, Singh K, Katzen J, Tomer Y, Chadwick AC, Musunuru K, Beers MF, Morrisey EE, Peranteau WH. Alapati D, et al. Among authors: katzen j. Sci Transl Med. 2019 Apr 17;11(488):eaav8375. doi: 10.1126/scitranslmed.aav8375. Sci Transl Med. 2019. PMID: 30996081 Free PMC article.
STAT3-BDNF-TrkB signalling promotes alveolar epithelial regeneration after lung injury.
Paris AJ, Hayer KE, Oved JH, Avgousti DC, Toulmin SA, Zepp JA, Zacharias WJ, Katzen JB, Basil MC, Kremp MM, Slamowitz AR, Jayachandran S, Sivakumar A, Dai N, Wang P, Frank DB, Eisenlohr LC, Cantu E 3rd, Beers MF, Weitzman MD, Morrisey EE, Worthen GS. Paris AJ, et al. Among authors: katzen jb. Nat Cell Biol. 2020 Oct;22(10):1197-1210. doi: 10.1038/s41556-020-0569-x. Epub 2020 Sep 28. Nat Cell Biol. 2020. PMID: 32989251 Free PMC article.
mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline.
Obraztsova K, Basil MC, Rue R, Sivakumar A, Lin SM, Mukhitov AR, Gritsiuta AI, Evans JF, Kopp M, Katzen J, Robichaud A, Atochina-Vasserman EN, Li S, Carl J, Babu A, Morley MP, Cantu E, Beers MF, Frank DB, Morrisey EE, Krymskaya VP. Obraztsova K, et al. Among authors: katzen j. Nat Commun. 2020 Nov 6;11(1):5640. doi: 10.1038/s41467-020-18979-4. Nat Commun. 2020. PMID: 33159078 Free PMC article.
Microstructured Hydrogels to Guide Self-Assembly and Function of Lung Alveolospheres.
Loebel C, Weiner AI, Eiken MK, Katzen JB, Morley MP, Bala V, Cardenas-Diaz FL, Davidson MD, Shiraishi K, Basil MC, Ferguson LT, Spence JR, Ochs M, Beers MF, Morrisey EE, Vaughan AE, Burdick JA. Loebel C, et al. Adv Mater. 2022 Jul;34(28):e2202992. doi: 10.1002/adma.202202992. Epub 2022 Jun 7. Adv Mater. 2022. PMID: 35522531 Free PMC article.
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